Understanding the relationship between cannabis use and attention-deficit/hyperactivity disorder

了解大麻使用与注意力缺陷/多动症之间的关系

• 批准号: 2874883
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2874883
• 关键词: Understanding; relationship; between; cannabis; use

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder, characterised by inattention, and hyperactivity/impulsivity. Cannabis use and cannabis use disorder (CUD) are prevalent amongst ADHD populations. Preliminary evidence suggests cannabis can alleviate core symptoms of ADHD. Current NICE guidelines that provide guidance on cannabis medicines in the UK do not consider ADHD, which represents a key gap in healthcare guidance. A lack of human research and methodological problems convolute findings of the harms and medicinal potential of cannabis in ADHD populations. This PhD will address these issues by exploring cannabis use, CUD, and the medicinal potential of cannabis in ADHD populations and controls. My research questions are "what is the association of cannabis use and ADHD, and what are the potential harms and benefits of cannabis use in people with ADHD?". Four studies will be conducted as part of this project; (1) systematic review and meta-analysis of prevalence of cannabis use and cannabis use disorder in individuals with ADHD, (2) a qualitative investigation of cannabis use and cannabis use disorder in adults with ADHD, (3) associations of medicinal cannabis on clinical outcomes of ADHD(4) exploring the acute effects of cannabis in adults with ADHD using ecological momentary assessment (EMA).I plan to undertake an overseas (KU Leuven, Belgium) residential EMA methods training course, and gain an internationally recognised qualification in EMA methods from this. I also plan to undertake SWDTP-Funded Bespoke Qualitative Training Workshops at the Centre for Qualitative Research (University of Bath), undertake training on systematic reviews and meta-analysis (Cochrane), MPlus, and core training in medical research from the GW4 MRC DTP. My research will be informed and disseminated to a Public and Patient Involvement (PPI) group, consisting of 10 individuals with lived experience of ADHD, with and without experience of using cannabis, whom I will meet with prior to beginning each study, and again upon completion of each study. My PhD will expand the field of ADHD and cannabis research by employing a series of advanced, novel, and cross-disciplinary methods. This research could produce findings with great social and economic importance and could inform understanding of how cannabis may harm and/or help people with ADHD which could inform NICE guidelines. My PhD aligns with the UKRI's strategic research theme 'Securing better health' and ESRC's strategic aim 'Improving health, wellbeing, and social care'.

注意力缺陷/多动障碍(ADHD)是一种普遍存在的神经发育障碍，以注意力不集中和多动/冲动为特征。大麻使用和大麻使用障碍(CUD)在ADHD人群中很普遍。初步证据表明，大麻可以缓解ADHD的核心症状。目前在英国提供大麻药物指导的NICE指南没有考虑ADHD，这是医疗指导中的一个关键差距。缺乏人类研究和方法学问题，令人费解地发现大麻在ADHD人群中的危害和药用潜力。这一博士学位将通过探索大麻的使用、CUD以及大麻在ADHD人群和对照人群中的药用潜力来解决这些问题。我的研究问题是“吸食大麻和ADHD之间有什么联系？吸食大麻对ADHD患者有什么潜在的危害和益处？”作为这个项目的一部分，将进行四项研究：(1)系统回顾和荟萃分析ADHD患者中大麻使用和大麻使用障碍的流行率，(2)对成人ADHD患者中大麻使用和大麻使用障碍的定性调查，(3)药用大麻对ADHD临床结局的影响(4)利用生态瞬时评估(EMA)探讨大麻对成人ADHD患者的急性影响。我计划在海外(比利时鲁汶)举办一项住院EMA方法培训课程，并由此获得国际认可的EMA方法资格。我还计划在巴斯大学定性研究中心举办由SWDTP资助的定制化定性培训讲习班，开展关于系统评价和荟萃分析(Cochrane)、MPlus的培训，以及GW4 MRC DTP的医学研究核心培训。我的研究将被告知并传播给公众和患者参与(PPI)小组，该小组由10名有ADHD生活经历、有和没有大麻使用经验的人组成，我将在每项研究开始之前和完成每项研究后再次与他们会面。我的博士学位将通过采用一系列先进的、新颖的和跨学科的方法来扩大ADHD和大麻研究的领域。这项研究可能产生具有重大社会和经济意义的发现，并可能有助于理解大麻如何伤害和/或帮助ADHD患者，从而为NICE指南提供参考。我的博士学位与UKRI的战略研究主题“确保更好的健康”和ESRC的战略目标“改善健康、福祉和社会关怀”是一致的。