Cortical Planning and Control of Smooth Pursuit

描述（由申请人提供）：平滑追踪是一种自愿的眼球运动，用于在物体移动时观察物体。虽然生理学家已经研究了自主扫视控制的许多方面，但大多数关于追踪神经控制的研究都将该系统视为对视网膜图像运动的反射性反应。灵长类动物的追踪系统是一个复杂的眼球运动系统，它已经进化到可以预测物体何时何地移动，并决定是否要追踪该物体。本研究的重点是了解皮质眼场如何合作来控制自愿的平稳追踪眼球运动。目的是： 1.比较皮质眼场执行追踪眼球运动所使用的预测信号和视网膜图像信号的强度 2. 确定皮层眼场如何相互作用以取消追踪运动。 3. 确定如何决定执行或取消追击行动。 这些实验的结果应该有助于我们了解大脑皮层是如何移动眼睛来有效地观察自然场景中移动的物体的。这项工作的结果应提供基本数据，以促进斜视和弱视等视力障碍的诊断和治疗，并开发修复装置，以帮助患有这些障碍的人。

DESCRIPTION (provided by applicant): Smooth pursuit is a voluntary eye movement that is used to view objects as they move. Although physiologists have studied many aspects of voluntary saccade control, most work on the neural control of pursuit has treated this system as if it responds reflexively to retinal-image motion. The pursuit system of primates is a sophisticated ocular movement system that has evolved to allow it to predict when and where an object will move, and to decide whether or not to pursue that object. The focus of the current grant period is to understand how the cortical eye fields cooperate to control voluntary smooth pursuit eye movements. Aims are to: 1. Compare the strength of predictive and retinal-image signals used by the cortical eye fields to execute a pursuit eye movement 2. Determine how the cortical eye fields interact to cancel a pursuit movement. 3. Determine how the decision is made to execute or cancel a pursuit movement. The results of these experiments should contribute to our knowledge of how the cortex moves the eyes to effectively view moving objects in the natural scene. The results of this work should provide basic data to facilitate diagnosis and treatment of disorders of vision such as strabismus and amblyopia, and to develop prosthetic devices to aid people who suffer from these disorders.