Cortical Planning and Control of Smooth Pursuit

平滑追踪的皮质规划与控制

• 批准号: 7123817
• 负责人: STEPHEN J HEINEN
• 金额: $ 33.65万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123817
• 关键词: Macaca mulatta; behavior test; computer data analysis; computer program /software; electrophysiology; electrostimulus; microelectrodes; neural information processing; neurons; neuroregulation; oculomotor nuclei; single cell analysis; smooth pursuit eye movement; vision tests; visual cortex; visual fields; visual stimulus

DESCRIPTION (provided by applicant): Smooth pursuit is a voluntary eye movement that is used to view objects as they move. Although physiologists have studied many aspects of voluntary saccade control, most work on the neural control of pursuit has treated this system as if it responds reflexively to retinal-image motion. The pursuit system of primates is a sophisticated ocular movement system that has evolved to allow it to predict when and where an object will move, and to decide whether or not to pursue that object. The focus of the current grant period is to understand how the cortical eye fields cooperate to control voluntary smooth pursuit eye movements. Aims are to: 1. Compare the strength of predictive and retinal-image signals used by the cortical eye fields to execute a pursuit eye movement 2. Determine how the cortical eye fields interact to cancel a pursuit movement. 3. Determine how the decision is made to execute or cancel a pursuit movement. The results of these experiments should contribute to our knowledge of how the cortex moves the eyes to effectively view moving objects in the natural scene. The results of this work should provide basic data to facilitate diagnosis and treatment of disorders of vision such as strabismus and amblyopia, and to develop prosthetic devices to aid people who suffer from these disorders.

描述（由申请人提供）：平滑追踪是一种自愿的眼球运动，用于在物体移动时观察它们。尽管生理学家已经研究了自愿扫视控制的许多方面，但大多数关于追踪的神经控制的工作都将该系统视为对视网膜图像运动做出反射性反应。灵长类动物的追踪系统是一种复杂的眼球运动系统，其进化使其能够预测物体将在何时何地移动，并决定是否追踪该物体。当前资助期的重点是了解皮质眼区如何合作来控制自愿平滑的追踪眼球运动。目标是： 1. 比较皮层眼区用于执行眼球追踪运动的预测信号和视网膜图像信号的强度 2. 确定皮质眼区如何相互作用以取消追踪运动。 3. 确定如何做出执行或取消追击动作的决定。 这些实验的结果应该有助于我们了解皮层如何移动眼睛以有效地观察自然场景中的移动物体。这项工作的结果应该提供基础数据，以促进斜视和弱视等视力障碍的诊断和治疗，并开发假肢装置来帮助患有这些疾病的人。