SAS ANAL OF CONFORMAT CHANGE THAT ACCOMP ACTIVATION IN TRANSCRIPT ACTIVATORS

转录激活剂中伴随激活的构象变化的 SAS 分析

• 批准号: 7182106
• 负责人: Katrina T Forest
• 金额: $ 0.44万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7182106
• 关键词: biomedical resource; biophysics; clinical research

DESCRIPTION (provided by applicant): We propose to continue operation of the Biophysics Collaborative Access Team (BioCAT) undulator beamline 18-1D at the Advanced Photon Source, Argonne National Laboratory. It's mission is to provide a national research resource for the study of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells. The goal of such research is to understand the detailed mechanisms of action of such systems at the molecular level. The techniques employed are non-crystalline x-ray diffraction, x-ray scattering and x-ray absorption emission spectroscopy. The BioCAT facilities provide a resource unique on the continent; only SPring-8 in Japan and the ESRF in France provide similar capabilities. New thrust areas include molecular shape determination from small angle scattering, high-resolution spectroscopy, micro-emission/absorption spectroscopy, and micro-diffraction. Major enhancements are planned for the areas of fiber diffraction, especially for the muscle diffraction program. Research and development efforts are also proposed in several areas directly related to improving data quality, reliability and efficiency of operation. Novel modes of operation are proposed that improve throughput and the quality of training.

描述（由申请人提供）：我们建议继续在Argonne National Laboratory的高级光子源的生物物理协作访问团队（BioCat）Undurotator Beam线18-1D运行。它的任务是提供国家研究资源，以研究部分有序的生物分子，生物分子的复合物和与活细胞中存在的条件相似的条件下。此类研究的目的是了解这种系统在分子水平上的详细作用机制。所采用的技术是非晶体X射线衍射，X射线散射和X射线吸收发射光谱。 BioCat设施为大陆提供了独特的资源；在日本和法国的ESRF仅春季-8提供类似的功能。新的推力区域包括分子形状从小角度散射，高分辨率光谱，微发射/吸收光谱和微差异。计划针对纤维衍射区域进行主要增强功能，尤其是对于肌肉衍射程序。还提出了与提高数据质量，可靠性和操作效率直接相关的几个领域的研发工作。提出了新型的操作方式，以改善吞吐量和训练质量。