CORE--GENETICS INITIATIVE COORDINATING CORE

核心--遗传学倡议协调核心

• 批准号: 6932713
• 负责人: RICHARD P MAYEUX
• 金额: $ 20.6万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932713
• 关键词: Alzheimer' s disease; biomedical facility; brain disorder diagnosis; case history; family genetics; human subject; human tissue; medical outreach /case finding; neuropathology; patient /disease registry; postmortem; tissue resource /registry

The Genetics Coordinating Core (GCC) at Columbia has been in existence for two years. The Core was initially supported through a supplement from the National Institute on Aging (NIA), Alzheimer's Disease Research Centers (ADRC/ADC) Program, with the goal of coordinating the collection of families in which two or more individuals have Alzheimer's disease from the collaborating centers. The overall program is entitled the NIA-Genetics Initiative for Late-Onset Alzheimer's Disease (NIA-LOAD Study). The collection of these families was designed using a multi-center approach that originally included 10 ADCs and was later expanded to include 18 centers for which Columbia University's ADRC has been the Coordinating Center. In addition, ADCs not included in the NIA Genetics Initiative have been able to submit families for consideration. Over the past year and a half, the GCC at the Columbia ADRC has developed, circulated and refined a procedures manual, reviewed and approved over 500 families for inclusion in the National Cell Repository for Alzheimer's Disease (NCRAD), specified the type of data to be collected and transmitted to NCRAD and have developed standardized format to collect age-at-onset, assess cognitive performance, collect biomarkers and autopsy material. The goals for the GCC over the next 5 years are to: expand the current collection of families by identifying and examining new families meeting NIA-LOAD criteria for inclusion, assist the participating centers to identify newly affected family members within existing families, develop and implement follow-up procedures, including autopsy, for the participating families and family members, facilitate and coordinate the recruitment of up to 1,000 individuals unrelated to the participating families without dementia to form "control" group similar in age, sex and ethnic background for association analyses by using similar methods to identify potential individuals, and develop and implement methods for standardized assessment of a series of quantitative traits for application in the NIA-LOAD study.

哥伦比亚的遗传学协调核心（GCC）已经存在了两年。该核心最初是通过美国国家老化研究所（NIA），阿尔茨海默氏病研究中心（ADRC/ADC）计划的补充来支持的，其目的是协调两个或多个人从合作中心获得阿尔茨海默氏病的家庭。整个计划的标题为NIA基因治疗倡议，该计划是晚期发病的阿尔茨海默氏病（NIA-LOAD研究）。这些家庭的收集是使用多中心方法设计的，该方法最初包括10个ADC，后来扩展到包括哥伦比亚大学ADRC成为协调中心的18个中心。此外，NIA遗传学倡议中未包括的ADC能够提交家庭以供考虑。 Over the past year and a half, the GCC at the Columbia ADRC has developed, circulated and refined a procedures manual, reviewed and approved over 500 families for inclusion in the National Cell Repository for Alzheimer's Disease (NCRAD), specified the type of data to be collected and transmitted to NCRAD and have developed standardized format to collect age-at-onset, assess cognitive performance, collect biomarkers and autopsy material.在接下来的5年中，海湾合作委员会的目标是：通过确定和检查满足NIA负载标准的新家庭来扩大当前家庭的收集，协助参与中心确定现有家庭中新受到影响的家庭成员， develop and implement follow-up procedures, including autopsy, for the participating families and family members, facilitate and coordinate the recruitment of up to 1,000 individuals unrelated to the participating families without dementia to form "control" group similar in age, sex and ethnic background for association analyses by using similar methods to identify potential individuals, and develop and implement methods for standardized assessment of a series of quantitative traits for application in the NIA-LOAD study.