CORE--CLINICAL CORE

核心--临床核心

• 批准号: 6932707
• 负责人: LAWRENCE S HONIG
• 金额: $ 36.91万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932707
• 关键词: Alzheimer' s disease; biomedical facility; brain disorder diagnosis; clinical research; dementia; diagnosis quality /standard; functional ability; health care referral /consultation; histopathology; human old age (65+); human subject; longitudinal human study; medical outreach /case finding; mental disorder diagnosis; neurogenetics; neuropathology; neuropsychological tests; patient /disease registry

The Clinical Core goals are to enroll, thoroughly clinically evaluate and characterize, and longitudinally follow elderly persons from diverse ethnic backgrounds, over the spectrum from those without dementia, to those with mild cognitive impairment (MCI), and with Alzheimer's disease and related dementias. The objectives are to further understanding of the etiologies of MCI in a community-representative sample of elderly individuals of differing cultural, ethnic, and socioeconomic origins, to assess factors involved in development of MCI and conversion of MCI to AD, and to provide well-characterized patients for research projects. The core will recruit a new cohort from a special population of about 500 community or apartment-dwelling individuals who receive home health care from nearby Isabella Geriatric Center. Most of these are not demented; most are Hispanic or African American. The focus will be assessment and follow-up of MCI, and the contributions of co-morbidities. The core will provide well-characterized subjects for research studies into aging and dementia, and will follow these subjects to autopsy. Rigorous standardized subject evaluations will include medical and neurological examinations, and neuropsychological and laboratory testing. Neuroimaging using MRJ will be performed in a subset of subjects. The value of brain autopsy will be emphasized, and the core will continue close interaction with the Neuropathology Core, since autopsy neuropathological examination generates definitive data regarding the disease processes during life, and also provides valuable brain tissue for proteomic, gene expression, mitochondrial, biochemical and genomic biological investigations. The Core will interact closely with the Data Management and Statistical Core, to ensure complete and highly standardized data collection and entry, allow consistent data analysis within the ADRC and allied projects that utilize ADRC subjects, and facilitate data transfer as specified by the National Alzheimer's Coordinating Center (NACC). Clinical Core activities will be a resource for a large number of federal, pharmaceutical, and foundation research projects, including clinical drug trials, neuroimaging studies, neuropsychological instrument trials, and research studies on risk factors.

临床核心目标是在没有痴呆症的患者（MCI）以及与阿尔茨海默氏病和相关的痴呆症的情况下，对来自不同种族背景的老年人进行彻底评估和表征，并纵向跟踪来自不同种族背景的老年人。这些目的是在社区代表性的样本中进一步了解MCI的病因，这些样本具有不同的文化，族裔和社会经济来源，以评估参与MCI发展和MCI转化为AD的因素，并为研究项目提供良好的患者。核心将从约500个社区或公寓居民的特殊人口中招募新的队列 从附近的伊莎贝拉老年中心获得家庭医疗保健的个人。其中大多数没有痴呆。大多数是西班牙裔或非裔美国人。重点将是对MCI的评估和随访以及合并症的贡献。核心将为对衰老和痴呆症的研究提供良好的受试者，并将遵循这些受试者进行尸检。严格的标准化受试者评估将包括医学和神经检查检查以及神经心理学和实验室测试。使用MRJ神经影像学将在受试者的一部分中进行。将强调脑尸检的价值，并且核心将继续与神经病理学核心进行密切相互作用，因为尸检 神经病理学检查生成有关生命中疾病过程的确定数据，还为蛋白质组学，基因表达，线粒体，生化和基因组生物学研究提供了有价值的脑组织。核心将与数据管理和统计核心紧密相互作用，以确保完整且高度标准化的数据收集和输入，允许在使用ADRC主题的ADRC和相关项目中进行一致的数据分析，并促进由国家阿尔茨海默氏症协调中心（NACC）指定的数据传输。临床核心活动将是大量联邦，药物和基金会研究项目的资源，包括临床药物试验，神经影像学研究，神经心理学仪器试验以及有关风险因素的研究。