CORE--CLINICAL CORE

临床核心提供了良好表征的患者和对照受试者，用于新的 在中心相关和合作项目的跨学科研究。目前纵向病例系列中增加的新受试者将仅包括正常衰老的人和轻度认知障碍（MCI）或轻度痴呆患者。这将满足中心研究人员的需求，并使他们能够进行尖端研究，以更好地了解阿尔茨海默病（AD）的临床和神经病理学变化，这些变化将阿尔茨海默病（AD）的最早阶段与正常衰老和其他老年人常见的神经退行性疾病区分开来。所有受试者均接受全面检查，包括神经心理学、实验室和影像学研究，并在共识会议上使用明确的诊断纳入和排除标准进行分类。受试者确定一名研究伙伴作为知情人，并鼓励受试者指定一名医疗保健倡导者，并临时同意进行尸检，以促进研究。年度评估提供纵向临床和神经心理学数据。核心将潜在受试者介绍给临床研究项目，与 国家阿尔茨海默氏症协调中心，并收集生物样本后，商定的协议，多中心项目。临床中心与教育中心密切合作，作为与社区的主要联系点，并协助提供教育材料和活动，以促进参与临床研究，激发学员和新研究人员的兴趣，并广泛传播研究进展。与少数民族卫星诊断和治疗中心在Ypsilanti家庭实践中心，它服务于大型非洲裔美国人和西班牙裔社区，临床核心确保了一个多样化的研究人群，从中吸引潜在的主题。核心还使用其收集的纵向数据进行开发工作，为中心研究人员提供 描述入组受试者的个体临床转变和疾病进展率的指标。

The Clinical Core provides well-characterized patients and control subjects for novel interdisciplinary research in Center-related and collaborative projects. New subjects added to the current Longitudinal Case Series will include only persons with normal aging and patients with mild cognitive impairment (MCI) or mild dementia. This will meet the needs of Center investigators and allow them to conduct cutting-edge research to understand better the clinical and neuropathological changes that distinguish the earliest stages of Alzheimer's disease (AD) from normal aging and from other neurodegenerative diseases commonly seen in the elderly. All subjects receive comprehensive examinations, including neuropsychological, laboratory and imaging studies, and are classified at a consensus conference using explicit diagnostic inclusion and exclusion criteria. Subjects identify a study partner who serves as an informant and are encouraged to name a health care advocate and give provisional consent for an autopsy to facilitate research. Annual assessments provide longitudinal clinical and neuropsychological data. The Core refers potential subjects to clinical research projects, shares data with the National Alzheimer's Coordinating Center, and collects biological samples following agreed upon protocols for multi-center projects. In close collaboration with the Education Core, the Clinical Core serves as the primary contact point with the community and assists with educational materials and activities to promote participation in clinical studies, stimulate the interest of trainees and new investigators, and disseminate research advances widely. In conjunction with the Minority Satellite Diagnostic and Treatment Center at the Ypsilanti Family Practice Center, which serves large African-American and Hispanic communities, the Clinical Core ensures a diverse research population from which to draw potential subjects. The Core also performs developmental work using its collected longitudinal data to provide Center investigators with metrics describing individual clinical transitions and rate of disease progression in enrolled participants.