CORE--CLINICAL

临床核心促进了MADRC的目标，并通过招募患者进行临床研究来为个别项目提供服务。在密歇根大学神经病学和老年精神病学诊所、神经心理学部门以及位于底特律和密歇根州北部农村的卫星诊断和治疗中心的合作者的帮助下，发现了阿尔茨海默病和阿尔茨海默病模拟患者。这提供了一个种族多样化的研究人群，包括农村和城市居民，反映了从症状轻微到严重受损的疾病严重程度的全部范围。正常对照受试者的招募与密歇根大学Pepper老年美国人独立中心的人类受试者核心协调。潜在研究对象接受排除标准。人口统计和照护者数据、痴呆严重程度、神经心理表现、运动体征和行为使用标准化程序进行表征。这些患者中的一部分人已经指定了一名医疗保健倡导者，并获得了尸检的临时同意，一组同意进行尸检的正常人被定期重新评估，并作为研究痴呆症的临床过程和临床病理相关性的资源。护士和社会工作者帮助招募患者进行研究，并为患者和护理人员提供支持和电话联系，以鼓励参与研究和家庭合作进行死后脑部检查。他们通过协调参与多项研究来确保适当的受试者选择和患者安全。临床核心为研究人员和其他核心提供有关痴呆症临床方面的咨询，并在中心的教育和推广活动中发挥重要作用。它促进了与其他阿尔茨海默病中心在数据共享和联合项目（如阿尔茨海默病合作研究）方面的合作。收集的数据与密歇根大学正在进行的老龄化流行病学研究有关，包括社区居住老年人的资产和健康动态研究以及接受机构护理的老年人的国家养老院居民评估工具。

The Clinical Core promotes the goals of the MADRC and s3erves individual projects by recruiting patients for clinical research studies. Patients with Alzheimer' s disease and Alzheimer's mimics are identified at the University of Michigan with the help of collaborators in the Neurology and Geropsychiatry Clinics and the Neuropsychology Division and at Satellite Diagnostic and Treatment Centers located in Detroit and in rural Northern Michigan. This provides an ethnically diverse research population including rural and urban residing subjects reflecting the full range of disease severity from minimally symptomatic to severely impaired. Recruitment of normal control subjects is coordinated with the Human Subjects Core of the Pepper Older Americans Independence Center at the University of Michigan. Potential research subjects receive exclusion criteria. Demographic and caregiver data, dementia severity, neuropsychological performance, motor signs and behavior are characterized using standardized procedures. A subset of these patients who have named a health care advocate and are given provisional consent for an autopsy, and a cohort of normal individuals who have consented to an autopsy are periodically reassessed and serve as a resource for studies examining the clinical course of dementing disorders and clinico-pathological correlations Nurses and social workers help recruit patients to research studies and provide patient and caregiver support and telephone contacts that encourage research participation and the cooperation of families in obtaining postmortem brain examinations. They assure appropriate subject selection and patient safety by coordinating participation in multiple studies. The Clinical Core provides consultation about clinical aspects of dementia to investigators and other Cores and plays a major role in educational and outreach activities of the Center. It promotes collaboration with other Alzheimer Disease Centers for datasharing and joint projects such as the Alzheimer Disease Cooperative Study. Data collected are linked to ongoing epidemiological studies of aging at the University of Michigan including the Assets and Health Dynamics Study of community dwelling elderly and the National Nursing Home Resident Assessment Instrument for elderly receiving institutional care.