CORE--CLINICAL

临床核心促进了MADRC的目标，并通过招募患者进行临床研究来服务于个人项目。密歇根大学在神经学和老年精神病学诊所、神经心理学部门以及位于底特律和密歇根北部农村的卫星诊断和治疗中心的合作者的帮助下，确认了患有阿尔茨海默氏症和阿尔茨海默氏症的患者。这提供了一个种族多样化的研究人群，包括居住在农村和城市的受试者，反映了从最轻微的症状到严重损害的各种疾病严重程度。正常对照受试者的招募是与密歇根大学胡椒老年美国人独立中心的人类受试者核心协调的。潜在的研究对象将被排除在外。人口统计和照顾者数据、痴呆症严重程度、神经心理表现、运动体征和行为使用标准化程序进行表征。这些患者中的一部分已经指定了卫生保健倡导者并获得了尸检的临时同意，以及一组同意进行尸检的正常人，他们被定期重新评估，并作为研究痴呆障碍的临床过程和临床病理相关性的研究资源。护士和社会工作者帮助招募患者进行研究，并提供患者和护理者支持以及电话联系，以鼓励研究参与和家人合作进行尸检。他们通过协调参与多项研究来确保适当的受试者选择和患者安全。临床核心为研究人员和其他核心提供有关痴呆症临床方面的咨询，并在该中心的教育和外联活动中发挥重要作用。它促进了与其他阿尔茨海默病中心在数据共享和联合项目方面的合作，例如阿尔茨海默病合作研究。收集的数据与密歇根大学正在进行的老龄化流行病学研究有关，包括社区居住老年人的资产和健康动态研究以及接受机构护理的全国养老院居民评估工具。

The Clinical Core promotes the goals of the MADRC and s3erves individual projects by recruiting patients for clinical research studies. Patients with Alzheimer' s disease and Alzheimer's mimics are identified at the University of Michigan with the help of collaborators in the Neurology and Geropsychiatry Clinics and the Neuropsychology Division and at Satellite Diagnostic and Treatment Centers located in Detroit and in rural Northern Michigan. This provides an ethnically diverse research population including rural and urban residing subjects reflecting the full range of disease severity from minimally symptomatic to severely impaired. Recruitment of normal control subjects is coordinated with the Human Subjects Core of the Pepper Older Americans Independence Center at the University of Michigan. Potential research subjects receive exclusion criteria. Demographic and caregiver data, dementia severity, neuropsychological performance, motor signs and behavior are characterized using standardized procedures. A subset of these patients who have named a health care advocate and are given provisional consent for an autopsy, and a cohort of normal individuals who have consented to an autopsy are periodically reassessed and serve as a resource for studies examining the clinical course of dementing disorders and clinico-pathological correlations Nurses and social workers help recruit patients to research studies and provide patient and caregiver support and telephone contacts that encourage research participation and the cooperation of families in obtaining postmortem brain examinations. They assure appropriate subject selection and patient safety by coordinating participation in multiple studies. The Clinical Core provides consultation about clinical aspects of dementia to investigators and other Cores and plays a major role in educational and outreach activities of the Center. It promotes collaboration with other Alzheimer Disease Centers for datasharing and joint projects such as the Alzheimer Disease Cooperative Study. Data collected are linked to ongoing epidemiological studies of aging at the University of Michigan including the Assets and Health Dynamics Study of community dwelling elderly and the National Nursing Home Resident Assessment Instrument for elderly receiving institutional care.