MICHIGAN ALZHEIMER?S DISEASE RESEARCH CENTER D(LONGITUDINAL COHORT) D MINORITY S

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being performed to learn more about the types of symptoms that develop in patients with Alzheimer's disease and related disorders. This study is a complement to an identical study being conducted at the University of Michigan Neurology Clinic. This study is conducted at the Ypsilanti Satellite with a goal of reaching target populations of underrepresented minorities. Participants in the study do not have to change their regular medical care. By observing how symptoms change over time, we hope to learn more about when and why particular symptoms develop. Individuals invited to enroll in this study are in good general health and have uncomplicated Alzheimer's disease or another related disorder that can affect memory or thinking ability. Once a participant enrolls in the study, he or she will be examined every six months at the Ypsilanti Satellite. Participants will also be given memory testing once a year. If a participant is no longer able to return for visits, study staff will contact the participant or participant's family by telephone to ask questions about the participant's health and progression of illness. These contacts will continue throughout the rest of the participant's life or until the participant withdraws from the study. Whenever possible, study procedures will occur at the same time as examinations required for regular medical care. However, if no regular clinical care is needed, participants will be asked to complete a 'study only' visit. As part of the study, medical records from regular Alzheimer's care will also be reviewed. Information from regular clinical care and study visits will be stored in a database at the University of Michigan. This data will be used in three ways: First, investigators named on the informed consent may access relevant data for participants they see prior to visits in order to monitor a participant's progression and prepare for their clinical evaluation. Second, separate research projects that are approved by the IRB and the Executive Committee may use data for research on dementia. In accordance with HIPAA, only the minimum necessary data would ever be provided to an approved separate project. Third, the data will also be stored in a national database at the National Alzheimer's Coordinating Center, a National Institutes of Health-funded Center. The data that goes to the NACC does not contain names, medical record numbers, or social security