MUTANT MOUSE INFORMATICS COORDINATING CENTER: MONITOR ANIMAL HLTH & GENETICS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。小鼠作为研究正常人类生物学和疾病的卓越研究工具，导致基因工程小鼠的产量急剧增加。美国国立卫生研究院关于“小鼠基因组学和遗传资源优先设置”的会议认可了突变小鼠区域资源中心（MMRRC）计划的概念，以确保这些有价值的小鼠继续提供给研究界。mmrrc包括一个互动研究资源中心网络，将导入、冷冻保存和分发选定的诱导突变小鼠菌株。该计划成功的关键是确保对动物健康和遗传完整性的高标准监测。同样重要的是建立一个有效的信息学网络，以协调mmrrc的活动。信息学协调中心（information Coordinating Center， ICC）将建立数据库，维护每个站点的库存数据，协调订单，提供每个站点保存的菌株的遗传和表型信息，并维护一个公共网站，提供对这些数据子集的访问并宣传菌株的可用性。NIH优先级设置小组建议mmrrc应与杰克逊实验室合作，以避免重复工作。杰克逊实验室在小鼠突变株的保存、繁殖和分布以及支持这些工作所需的信息学资源的开发方面拥有丰富的经验。我们建议在杰克逊实验室建立国际信息中心，并为MMRRC项目开发和维护信息网络。我们建议1)开发和维护一个库存数据库，其中包含mmrrc和Jackson实验室诱导突变资源中所有菌株的最新数据，并与其他数据库建立适当的链接；2)开发和实施连接mmrrc和ICC的信息网络；3)开发和维护ICC网页，提供应变数据、在线订购和信息请求表格以及适当的链接；4)建立和实施协调调查员支持服务和分配的程序。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS The mouse as the preeminent research tool for the investigation of normal human biology and disease has lead to a dramatic increase in the production of genetically engineered mice. The NIH meeting on "Priority Setting for Mouse Genomics and Genetics Resources" endorsed the concept of a Mutant Mouse Regional Resource Centers (MMRRC) program to ensure the continued availability of these valuable mice to the research community. The MMRRCs comprise a network of interactive research resource centers that will import, cryopreserve, and distribute selected induced mutant strains of mice. Crucial to the success of this program is the insurance of high standards for monitoring animal health and genetic integrity. Equally important is the establishment of an efficient informatics network to coordinate the activities of the MMRRCs. An Informatics Coordinating Center (ICC) will develop databases to maintain data on inventories at each site, coordinate orders, provide genetic and phenotypic information about strains held at each site, and maintain a public web site that will provide access to subsets of these data and advertise the availability of strains. The NIH priority setting group suggested that the MMRRCs should collaborate with The Jackson Laboratory to avoid duplication of effort. The Jackson Laboratory has extensive experience in the preservation, propagation, and distribution of mutant strains of mice, and in the development of informatics resources needed to support these efforts. We propose to establish the ICC at The Jackson Laboratory and to develop and maintain the informatics network for the MMRRC program. We propose to 1) develop and maintain an inventory database containing updated data on all strains maintained in the MMRRCs and The Jackson Laboratory''s Induced Mutant Resource, with appropriate links to other databases; 2) develop and implement an information network linking the MMRRCs and the ICC; 3) develop and maintain an ICC Web page to provide access to strain data, on-line ordering and information request forms, and appropriate links; and 4) establish and implement procedures for coordinating investigator support services and distribution.