Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers

项目总结--总体 突变小鼠资源和研究中心(MMRRC)是美国国立卫生研究院最重要的 基因工程和自发突变的小鼠等位基因的冷冻保存和分布 活体小鼠、种质和胚胎干细胞等细胞系。MMRRC的四个繁育和分布 加州大学戴维斯分校、北卡罗来纳大学教堂山分校、密歇根大学哥伦比亚分校和杰克逊实验室(ME)的设施包括 通过信息学、协调和服务中心(ICSC)集中组织，该中心维护 MMRRC的网站，并为生物医学研究社区提供客户服务。因此， ICSC负责所有MMRRC订单的处理，菌株捐赠的协调，数据管理，指标， 以及该联盟的公众教育和外展活动。此特定应用程序的目标是 公务员制度委员会在加州大学戴维斯分校继续运作。这将通过三个指定的核心来完成 这迎合了MMRRC(1)协调，(2)客户服务和公共关系，以及(3)信息学。每个核心的 项目负责人将指导旨在扩大MMRRC的运营和卓越的活动。更确切地说， 协调核心将促进内部和外部MMRRC的互动和协作，管理 技术人员，与ORIP/DPCPSI/OD/NIH计划官员组织MMRRC交流，并协调 进度报告以及现场访问。客户服务和公共关系核心将作为第一点 还可以使用基于网络的交互，联系研究社区进行捐赠、数据和订单查询 作为在专业会议上的面对面代表，除了有针对性地努力提高对 MMRRC是一个有价值的研究资源。信息学核心将负责开发， 实施、扩展和维护MMRRC网站、与以下方面相关的关系数据库 所有公务员制度委员会服务、在公务员制度委员会托管的通信服务、指标报告和分析性营销 努力。公务员制度委员会还将开展一项应用研究项目，审查MMRRC对以下方面的影响 整个研究社区，使用监督的文献分析。在目前的领导下，公务员制度委员会-- 协调的MMRRC财团将其用户基础增加了50%，持有量几乎翻了一番，并订购了 2019年达到历史新高。这是通过简化捐赠和订单处理以及 通过有针对性的社交媒体和电子邮件活动，利用创新的、以用户为中心的信息技术。这个 因此，公务员制度委员会在加州大学戴维斯分校的运作非常适合这一筹资机会的目的，即促进 MMRRC作为NIH的首选资源，确保最高标准的实验设计和质量控制 目的：优化突变小鼠研究的重复性。这一点意义重大，因为它直接迎合了美国国立卫生研究院 促进研究的使命是为人类健康进步产生强有力和可重复的结果。

PROJECT SUMMARY – OVERALL The Mutant Mouse Resource and Research Centers (MMRRC) is the NIH’s premier repository for the cryopreservation and distribution of genetically engineered and spontaneously mutated mouse alleles held as live mice, germplasm, and embryonic stem and other cell lines. The MMRRC’s four breeding and distribution facilities at UC Davis (CA), UNC Chapel Hill (NC), UM Columbia (MO), and The Jackson Laboratories (ME) are centrally organized through the Informatics, Coordination and Service Center (ICSC), which maintains the MMRRC’s web presence and provides customer service to the biomedical research community. As such, the ICSC is responsible for all MMRRC order processing, the coordination of strain donations, data curation, metrics, and the consortium’s public education & outreach campaign. The objective of this particular application is the continued operation of the ICSC at the UC Davis campus. This will be accomplished with three designated Cores that cater to MMRRC (1) Coordination, (2) Customer Service & Public Relations, and (3) Informatics. Each Core’s Project Lead will direct activities designed to expand the MMRRC’s operations and excellence. More specifically, the Coordination Core will facilitate internal as well as external MMRRC interactions and collaborations, manage technical staff, organize MMRRC exchanges with the ORIP/DPCPSI/OD/NIH Program Official, and coordinate progress reports as well as site visits. The Customer Service & Public Relation Core will act as the first point of contact for donation, data, and order inquiries from the research community, using web-based interaction as well as face-to-face representation at professional conferences in addition to targeted efforts to raise awareness of the MMRRC as a valuable research resource. The Informatics Core will be responsible for the development, implementation, expansion, and maintenance of the MMRRC website, the relational databases associated with all ICSC services, communication services hosted at the ICSC, metrics reporting, and the analytical marketing effort. The ICSC will furthermore engage an Applied Research Project examining the impact of the MMRRC on the research community at large, using supervised literature analyses. Under its current leadership, the ICSC- coordinated MMRRC consortium has increased its user base by >50%, nearly doubled its holdings, and orders reached an all-time high in 2019. This was accomplished by streamlining donation and order processing and through targeted social media and email campaigns with innovative, user-centered information technology. The ICSC operation at UC Davis is, hence, well suited for this funding opportunity’s purpose, namely to promote the MMRRC as the NIH go-to resource to ensure the highest standards of experimental design and quality control to optimize the reproducibility of mutant mouse research. This is significant because it caters directly to the NIH mission of promoting research to generate robust and reproducible results for the advancement of human health.