MUTANT MOUSE INFORMATICS COORDINATING CENTER: MONITOR ANIMAL HLTH & GENETICS

突变小鼠信息学协调中心：监测动物 HLTH

• 批准号: 7360413
• 负责人: LARRY E MOBRAATEN
• 金额: $ 20.1万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7360413
• 关键词: MUTANT; MOUSE; INFORMATICS; COORDINATING; CENTER

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The mouse as the preeminent research tool for the investigation of normal human biology and disease has lead to a dramatic increase in the production of genetically engineered mice. The NIH meeting on "Priority Setting for Mouse Genomics and Genetics Resources" endorsed the concept of a Mutant Mouse Regional Resource Centers (MMRRC) program to ensure the continued availability of these valuable mice to the research community. The MMRRCs comprise a network of interactive research resource centers that will import, cryopreserve, and distribute selected induced mutant strains of mice. Crucial to the success of this program is the insurance of high standards for monitoring animal health and genetic integrity. Equally important is the establishment of an efficient informatics network to coordinate the activities of the MMRRCs. An Informatics Coordinating Center (ICC) will develop databases to maintain data on inventories at each site, coordinate orders, provide genetic and phenotypic information about strains held at each site, and maintain a public web site that will provide access to subsets of these data and advertise the availability of strains. The NIH priority setting group suggested that the MMRRCs should collaborate with The Jackson Laboratory to avoid duplication of effort. The Jackson Laboratory has extensive experience in the preservation, propagation, and distribution of mutant strains of mice, and in the development of informatics resources needed to support these efforts. We propose to establish the ICC at The Jackson Laboratory and to develop and maintain the informatics network for the MMRRC program. We propose to 1) develop and maintain an inventory database containing updated data on all strains maintained in the MMRRCs and The Jackson Laboratory''s Induced Mutant Resource, with appropriate links to other databases; 2) develop and implement an information network linking the MMRRCs and the ICC; 3) develop and maintain an ICC Web page to provide access to strain data, on-line ordering and information request forms, and appropriate links; and 4) establish and implement procedures for coordinating investigator support services and distribution.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。小鼠作为研究正常人类生物学和疾病的卓越研究工具，导致基因工程小鼠的生产急剧增加。美国国立卫生研究院关于“小鼠基因组学和遗传资源优先级设置”的会议批准了突变小鼠区域资源中心（MMRRC）计划的概念，以确保这些有价值的小鼠继续提供给研究界。MMRRCs包括一个互动研究资源中心网络，将进口，冷冻保存和分配选定的诱导突变小鼠品系。该计划成功的关键是确保高标准的动物健康和遗传完整性监测。同样重要的是建立一个有效的信息网络，以协调千年发展目标监测和报告区域中心的活动。信息学协调中心（ICC）将开发数据库，以维护每个研究中心的库存数据，协调订单，提供每个研究中心保存的菌株的遗传和表型信息，并维护一个公共网站，该网站将提供这些数据的子集，并宣传菌株的可用性。NIH优先事项设定小组建议MMRRCs应与杰克逊实验室合作，以避免重复工作。杰克逊实验室在小鼠突变品系的保存、繁殖和分布以及支持这些努力所需的信息学资源的开发方面具有丰富的经验。我们建议在杰克逊实验室建立ICC，并为MMRRC计划开发和维护信息网络。我们建议：1）建立和维护一个库存数据库，其中包含MMRRCs和杰克逊实验室诱导突变资源中保存的所有菌株的最新数据，并与其他数据库建立适当的链接; 2）建立和实施一个连接MMRRCs和ICC的信息网络; 3）开发和维护ICC网页，以提供应变数据、在线订购和信息请求表格以及适当的链接;以及4）建立和实施协调研究者支持服务和分发的程序。