Conference on the Diagnosis of Multiple System Atrophy
多系统萎缩诊断会议
基本信息
- 批准号:7113588
- 负责人:
- 金额:$ 5.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2007-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Recent advances in structural and functional imaging and in neuropathology have revealed distinctive changes in multiple system atrophy (MSA), and now can be added to current diagnostic guidelines, which utilize clinical criteria alone. This is a proposal to plan, develop and convene a consensus conference on the diagnosis of MSA and create a new set of diagnostic criteria incorporating recent advances in imaging and neuropathology. A Steering Committee has selected the participants from a large group of internationally recognized experts in the specific manifestations of MSA. Participants were selected based upon their expertise in the diagnosis of MSA, and special efforts were made to include women and minorities. In advance of the conference, the Steering Committee will divide the participants into five groups based upon their specific expertise, appoint a chair for each group, and give each group the task of developing draft consensus guidelines from its unique perspective. The groups include neuropathology, imaging, and the parkinsonian, cerebellar and autonomic manifestations of MSA. Upon receipt of these draft guidelines, the Steering Committee will integrate them and develop a unified draft consensus document for consideration at the conference. The conference will be convened in Boston on April 26 and 27, 2007 in association with the annual meeting of the American Academy of Neurology. Utilizing consensus methodology, the participants will develop new guidelines for the clinical diagnosis of MSA based upon the draft from the Steering Committee. The results will be incorporated into abstracts for appropriate clinical meetings and a full manuscript will be developed for publication in a prominent neurological journal. MSA, Parkinson's disease and the ataxias are within the province of interest of NINDS, which funds a program project on MSA and numerous grants in the remaining areas. Three of the participants in the current proposal are investigators in the NINDS Program Project on MSA. Relevance to public health: MSA is a progressive neurodegenerative disorder that is often mistaken for Parkinson's disease. Accurate early diagnosis is important for medical therapy of many of the treatable features of MSA and for selecting subjects for clinical trials of new medications. This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria.
描述(申请人提供):结构和功能成像以及神经病理学的最新进展揭示了多系统萎缩(MSA)的独特变化,现在可以添加到仅使用临床标准的现有诊断指南中。这是一项关于计划、开发和召开一次关于MSA诊断的共识会议的建议,并创建一套新的诊断标准,纳入成像和神经病理学的最新进展。一个指导委员会从一大批国际公认的MSA具体表现方面的专家中挑选了与会者。参与者是根据他们在诊断多发性硬化症方面的专门知识挑选出来的,并作出了特别努力,将妇女和少数群体包括在内。在会议之前,指导委员会将根据与会者的具体专长将他们分成五个小组,为每个小组指定一名主席,并赋予每个小组从其独特的角度制定协商一致准则草案的任务。这些组包括神经病理学、影像学以及帕金森病、小脑和自主神经的MSA表现。在收到这些准则草案后,指导委员会将把它们结合起来,制定一份统一的协商一致文件草案,供大会审议。这次会议将于2007年4月26日和27日在波士顿召开,同时召开的还有美国神经病学学会年会。利用协商一致的方法,与会者将根据指导委员会的草案制定新的MSA临床诊断指南。研究结果将被纳入适当的临床会议的摘要中,完整的手稿将被开发出来,发表在一本著名的神经学杂志上。MSA、帕金森氏病和共济失调都在NINDS的关注范围内,NINDS为MSA的一个项目提供资金,并在其余地区提供大量赠款。当前提案的参与者中有三人是MSA上NINDS计划项目的调查人员。与公共健康相关:MSA是一种进行性神经退行性疾病,经常被误认为帕金森氏症。准确的早期诊断对于MSA的许多可治疗特征的医学治疗和新药临床试验的选择对象是重要的。本次会议将利用新的影像和神经病理学标准制定新的诊断指南,以协助早期诊断。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SID GILMAN', 18)}}的其他基金
NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES
神经退行性疾病中睡眠障碍的神经化学基础
- 批准号:
7603709 - 财政年份:2007
- 资助金额:
$ 5.5万 - 项目类别:
PATHOGENESIS AND DIAGNOSIS OF MULTIPLE SYSTEM ATROPHY
多系统萎缩的发病机制和诊断
- 批准号:
7603764 - 财政年份:2007
- 资助金额:
$ 5.5万 - 项目类别:
PATHOGENESIS AND DIAGNOSIS OF MULTIPLE SYSTEM ATROPHY
多系统萎缩的发病机制和诊断
- 批准号:
7376596 - 财政年份:2006
- 资助金额:
$ 5.5万 - 项目类别:
NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES
神经退行性疾病中睡眠障碍的神经化学基础
- 批准号:
7376508 - 财政年份:2006
- 资助金额:
$ 5.5万 - 项目类别:
NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES
神经退行性疾病中睡眠障碍的神经化学基础
- 批准号:
7199827 - 财政年份:2005
- 资助金额:
$ 5.5万 - 项目类别:
PATHOGENESIS AND DIAGNOSIS OF MULTIPLE SYSTEM ATROPHY
多系统萎缩的发病机制和诊断
- 批准号:
7199924 - 财政年份:2005
- 资助金额:
$ 5.5万 - 项目类别:
Neurochemical Basis of Sleep Disorders in Neurodegenerative Diseases
神经退行性疾病睡眠障碍的神经化学基础
- 批准号:
7039799 - 财政年份:2004
- 资助金额:
$ 5.5万 - 项目类别:
MONOAMINERGIC PATHWAYS IN NEURODEGENERATIVE DISEASES
神经退行性疾病中的单胺能途径
- 批准号:
6315624 - 财政年份:2000
- 资助金额:
$ 5.5万 - 项目类别: