NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES

神经退行性疾病中睡眠障碍的神经化学基础

• 批准号: 7376508
• 负责人: SID GILMAN
• 金额: $ 5.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376508
• 关键词: Alzheimer' s disease; Lewy body; Parkinson' s disease; REM sleep; aging; atrophy; behavior disorders; brain; breast feeding; conditioning; dementia; density; emotions; eye movements; ligands; motivation; neural degeneration; neurotransmitters; positron emission tomography; progressive supranuclear palsy; sleep; sleep apnea; sleep disorders

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying sleep disturbances accompanying the neurodegenerative diseases Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), Parkinson's Disease (PD), Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Huntington's Disease (HD), Sporadic Olivopontocerebellar Atrophy (OPCA), and Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). These diseases are associated with several sleep disorders, including rapid eye movement (REM) sleep behavior disorder (RBD), and both obstructive and central sleep apnea. The present study is designed to investigate the neurochemical basis of RBD and OSA in patients with these neurological disorders, and in patients with RBD alone. We will use a functional imaging technique, positron emission tomography (PET), with two biochemical agents (ligands) to study neurotransmitter densities in the brain. The agents include [11C]dihydrotetrabenazine ([11C]DTBZ) and [11C]methylpiperidin(c)4(c)yl propitionate ([11C]PMP). These studies will help us understand the biochemical basis of RBD and OSA and this information will be used to inform our attempts at treatment for these symptoms. We will study 190 people who have been diagnosed with MSA, PSP, PD, AD, DLB, and sOPCA, Idiopathic RBD, and normal controls. Research subjects must be between the ages of 45 and 75. We are interested in studying both men and women, and in studying people from all ethnic and racial backgrounds. Women may not take part in this project if they are pregnant or breast-feeding a baby. Individuals may not take part in this project if they have a neurologic or psychiatric condition that might interfere with this study. They may not take part in this project if they have a medical illness or a prior significant illness that might affect the project.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。我们正在研究伴随神经退行性疾病多系统萎缩（MSA）、进行性核上性麻痹（PSP）、帕金森病（PD）、阿尔茨海默病（AD）、路易体痴呆（DLB）、亨廷顿病（HD）、散发性橄榄脑桥小脑萎缩（OPCA）和 特发性快速眼动 (REM) 睡眠行为障碍 (RBD)。这些疾病与多种睡眠障碍有关，包括快速眼动 (REM) 睡眠行为障碍 (RBD) 以及阻塞性和中枢性睡眠呼吸暂停。本研究旨在调查患有这些神经系统疾病的患者以及仅患有 RBD 的患者中 RBD 和 OSA 的神经化学基础。我们将使用功能成像技术、正电子发射断层扫描 (PET) 和两种生化试剂（配体）来研究大脑中的神经递质密度。这些试剂包括[11C]二氢丁苯那嗪([11C]DTBZ)和[11C]甲基哌啶(c)4(c)基丙酸酯([11C]PMP)。这些研究将帮助我们了解 RBD 和 OSA 的生化基础，并且这些信息将用于指导我们尝试治疗这些症状。我们将研究 190 名被诊断患有 MSA、PSP、PD、AD、DLB 和 sOPCA、特发性 RBD 的人和正常对照者。研究对象的年龄必须在 45 岁至 75 岁之间。我们对研究男性和女性以及来自所有民族和种族背景的人感兴趣。如果女性怀孕或正在哺乳婴儿，则不得参加此项目。如果个人患有可能干扰本研究的神经或精神疾病，则不得参加本项目。如果他们患有疾病或之前患有可能影响项目的重大疾病，则他们可能无法参加该项目。