NEUROCHEMICAL BASIS OF SLEEP DISORDERS IN NEURODEGENERATIVE DISEASES

神经退行性疾病中睡眠障碍的神经化学基础

• 批准号: 7603709
• 负责人: SID GILMAN
• 金额: $ 1.49万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603709
• 关键词: Affect; Age; Alzheimer' s Disease; Biochemical; Brain; Breast Feeding; Central Sleep Apnea; Computer Retrieval of Information on Scientific Projects Database; Condition; Diagnosis; Disease; Functional Imaging; Funding; Grant; Huntington Disease; Idiopathic Olivopontocerebellar Atrophies; Imaging Techniques; Individual; Institution; Lewy Body Disease; Ligands; Medical; Multiple System Atrophy; Neurodegenerative Disorders; Neurologic; Neurotransmitters; OSA; Parkinson Disease; Patient currently pregnant; Patients; Positron-Emission Tomography; Progressive Supranuclear Palsy; REM Sleep Behavior Disorder; RNA Recognition Motif; Research; Research Personnel; Research Subjects; Resources; Sleep Disorders; Sleep disturbances; Source; Symptoms; United States National Institutes of Health; Woman; base; density; design; dihydrotetrabenazine; interest; men; nervous system disorder; neurochemistry; racial and ethnic; rapid eye movement

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are studying sleep disturbances accompanying the neurodegenerative diseases Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), Parkinson's Disease (PD), Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Huntington's Disease (HD), Sporadic Olivopontocerebellar Atrophy (OPCA), and Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). These diseases are associated with several sleep disorders, including rapid eye movement (REM) sleep behavior disorder (RBD), and both obstructive and central sleep apnea. The present study is designed to investigate the neurochemical basis of RBD and OSA in patients with these neurological disorders, and in patients with RBD alone. We will use a functional imaging technique, positron emission tomography (PET), with two biochemical agents (ligands) to study neurotransmitter densities in the brain. The agents include [11C]dihydrotetrabenazine ([11C]DTBZ) and [11C]methylpiperidin(c)4(c)yl propitionate ([11C]PMP). These studies will help us understand the biochemical basis of RBD and OSA and this information will be used to inform our attempts at treatment for these symptoms. We will study 190 people who have been diagnosed with MSA, PSP, PD, AD, DLB, and sOPCA, Idiopathic RBD, and normal controls. Research subjects must be between the ages of 45 and 75. We are interested in studying both men and women, and in studying people from all ethnic and racial backgrounds. Women may not take part in this project if they are pregnant or breast-feeding a baby. Individuals may not take part in this project if they have a neurologic or psychiatric condition that might interfere with this study. They may not take part in this project if they have a medical illness or a prior significant illness that might affect the project.'

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在研究伴随神经退行性疾病多系统萎缩（MSA）、进行性核上性麻痹（PSP）、帕金森病（PD）、阿尔茨海默病（AD）、路易体痴呆（DLB）、亨廷顿病（HD）、散发性橄榄体脑桥小脑萎缩（OPCA）和特发性快速眼动（REM）睡眠行为障碍（RBD）的睡眠障碍。 这些疾病与几种睡眠障碍有关，包括快速眼动（REM）睡眠行为障碍（RBD），以及阻塞性和中枢性睡眠呼吸暂停。本研究旨在调查RBD和OSA在这些神经系统疾病患者中的神经化学基础，以及单独RBD患者。我们将使用功能成像技术，正电子发射断层扫描（PET），与两个生化试剂（配体），以研究大脑中的神经递质密度。所述药剂包括[11 C]二氢丁苯那嗪（[11 C]DTBZ）和[11 C]甲基哌啶（c）4（c）基丙炔（[11 C]PMP）。这些研究将帮助我们了解RBD和OSA的生化基础，这些信息将用于指导我们治疗这些症状的尝试。我们将研究190名被诊断为MSA、PSP、PD、AD、DLB和sOPCA、特发性RBD的患者和正常对照。研究对象年龄必须在45至75岁之间。我们有兴趣研究男性和女性，并在研究来自所有民族和种族背景的人。如果女性怀孕或哺乳婴儿，则不得参加该项目。如果个人患有可能干扰本研究的神经系统或精神疾病，则不得参与本项目。如果他们患有可能影响项目的医学疾病或既往重大疾病，则不得参加本项目。'