BD BIOSCIENCES FACS CANTO FLOW CYTOMETER: AIDS
BD Biosciences FACS CANTO 流式细胞仪:艾滋病
基本信息
- 批准号:7335103
- 负责人:
- 金额:$ 5.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-01 至 2007-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This application requests funds to purchase the BD Biosciences FACS Canto flow cytometer for the Laboratory for Cellular and Tissue Engineering (LCTE) at the University of Alabama at Birmingham. The instrument will be used to replace a 12 year old BD Biosciences FACS Sort cytometer that has required frequent servicing that at times has impacted the functioning of the laboratory. This instrumentation will allow the laboratory to continue to serve its users well into the future and to expand functionality to allow six-color flow cytometry. The LCTE is a CLIA, CAP, and FACT-compliant core facility supported by the Comprehensive Cancer Center, the Center for AIDS Research, and the Sickle Cell Center. The LCTE provides a platform for translation of promising cellular therapy (including gene-modified cellular therapy) protocols for UAB investigators. The facility provides support from the earliest level of preclinical development to the preparation of clinical grade materials and submission of INDs. Many cell products that are generated in the LCTE are prepared in a clean room environment. The current flow cytometer is located in an adjacent laboratory with a pass-through to the clean suites allowing immediate on-site analysis and consultation with the team that is preparing the graft. Since the graft engineering work often requires multiple steps with flow cytometric analysis required prior to critical decisions during processing, transport of the specimens to another facility for analysis would unnecessarily prolong the processing and potentially compromise the product. In addition, when the LCTE cytometer is not being used for cellular graft evaluation, it is available for overflow work from the Comprehensive Cancer Center, Center for AIDS Research, and the Brain Tumor SPORE NIH-funded investigators that require a 51 OK approved instrument in a CLIA-approved laboratory for their protocols. The Principal Investigator has recently been funded by the University of Alabama Health Services Foundation to undertake a major expansion of the LCTE to include protocols for somatic cell therapy, myocardial regeneration, gene therapy for sickle cell disease, dendritic cell and regulatory cell therapy for autoimmune disorders, and bone regeneration. These protocols, in addition to existing hematopoietic cell therapy and immunotherapy trials nearing approval, will substantially increase the number of users over the next two years. The laboratory will require an instrument that will serve the laboratory in the development and execution of advanced cell therapy trials.
这个子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是用于拨款的,而不一定是用于调查人员的机构。描述(由申请人提供):本申请申请为伯明翰阿拉巴马大学细胞与组织工程实验室(LCTE)购买BD Biosciences FACS Canto流式细胞仪。该仪器将用于取代已有12年历史的BD Biosciences FACS分类细胞仪,该仪器需要频繁维修,有时会影响实验室的功能。这一仪器将允许实验室在未来继续为其用户提供良好的服务,并扩展功能以实现六色流式细胞术。LCTE是由综合癌症中心、艾滋病研究中心和镰刀细胞中心支持的CLIA、CAP和符合事实的核心设施。LCTE为UAB研究人员提供了一个翻译有前景的细胞治疗(包括基因修饰的细胞治疗)方案的平台。该设施提供从临床前开发的最早水平到临床分级材料的准备和IND的提交的支持。在LCTE中产生的许多电池产品是在无尘室环境中制备的。目前的流式细胞仪位于相邻的实验室,有通向干净套间的通道,可以立即进行现场分析,并与准备移植的团队进行咨询。由于移植工程工作通常需要多个步骤,在处理过程中的关键决定之前需要进行流式细胞仪分析,因此将标本运送到另一个设施进行分析将不必要地延长处理时间,并可能损害产品。此外,当LCTE细胞仪不用于细胞移植评估时,它可用于综合癌症中心、艾滋病研究中心和NIH资助的脑瘤孢子研究人员的溢出工作,这些研究人员需要在CLIA批准的实验室中使用51OK批准的仪器才能进行他们的方案。首席调查员最近得到阿拉巴马大学健康服务基金会的资助,对LCTE进行了重大扩展,将体细胞治疗、心肌再生、镰状细胞病的基因治疗、自身免疫性疾病的树突状细胞和调节细胞治疗以及骨再生的方案包括在内。这些方案,加上即将获得批准的现有造血细胞疗法和免疫疗法试验,将在未来两年大幅增加使用者的数量。该实验室将需要一种仪器,为实验室开发和执行先进的细胞治疗试验提供服务。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAWRENCE S LAMB其他文献
LAWRENCE S LAMB的其他文献
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{{ truncateString('LAWRENCE S LAMB', 18)}}的其他基金
Donor Innate Lymphocyte Infusion Product for Immunotherapy of Glioblastoma Multif
用于多发性胶质母细胞瘤免疫治疗的供体先天淋巴细胞输注产品
- 批准号:
7772397 - 财政年份:2010
- 资助金额:
$ 5.24万 - 项目类别:
Feasibility of gamma/delta T cell immunotherapy for glioblastoma
γ/δ T 细胞免疫治疗胶质母细胞瘤的可行性
- 批准号:
7487823 - 财政年份:2007
- 资助金额:
$ 5.24万 - 项目类别:
Feasibility of gamma/delta T cell immunotherapy for glioblastoma
γ/δ T 细胞免疫治疗胶质母细胞瘤的可行性
- 批准号:
7313172 - 财政年份:2007
- 资助金额:
$ 5.24万 - 项目类别:
Feasibility of gamma/delta T cell immunotherapy for glioblastoma
γ/δ T 细胞免疫治疗胶质母细胞瘤的可行性
- 批准号:
7869514 - 财政年份:2007
- 资助金额:
$ 5.24万 - 项目类别:
BD BIOSCIENCES FACS CANTO FLOW CYTOMETER: SICKLE CELL DISEASE, GENE THERAPY
BD BIOSCIENCES FACS CANTO 流式细胞仪:镰状细胞病,基因治疗
- 批准号:
7335105 - 财政年份:2006
- 资助金额:
$ 5.24万 - 项目类别:
BD BIOSCIENCES FACS CANTO FLOW CYTOMETER; IMMUNOLOGY, CELL BIOLOGY
BD Biosciences FACS CANTO 流式细胞仪;
- 批准号:
7335107 - 财政年份:2006
- 资助金额:
$ 5.24万 - 项目类别:
BD BIOSCIENCES FACS CANTO FLOW CYTOMETER: CANCER: MELANOMA, GLIOMA
BD Biosciences FACS CANTO 流式细胞仪:癌症:黑色素瘤、神经胶质瘤
- 批准号:
7335104 - 财政年份:2006
- 资助金额:
$ 5.24万 - 项目类别:
BD Biosciences FACS Canto Flow Cytometer
BD Biosciences FACS Canto 流式细胞仪
- 批准号:
7046224 - 财政年份:2006
- 资助金额:
$ 5.24万 - 项目类别:
BD BIOSCIENCES FACS CANTO FLOW CYTOMETER: MOUSE STEM CELLS: ADULT & EMBRYONIC
BD Biosciences FACS CANTO 流式细胞仪:小鼠干细胞:成人
- 批准号:
7335106 - 财政年份:2006
- 资助金额:
$ 5.24万 - 项目类别:
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