X-SPECTTM for Functional & Anatomic Imaging In Vivo

X-SPECTTM 功能性

• 批准号: 7047657
• 负责人: Sissy M Jhiang
• 金额: $ 34.99万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047657
• 关键词: birth; neoplasm /cancer; training; university

DESCRIPTION (provided by applicant): An X-SPECT imaging system made by Gamma Medica, Inc. is requested in this Shared Instrument Grant application. X-SPECT(tm) is a dual-modality small animal imaging system that combines x-ray Computed Tomography (CT) and Single Photon Emission Computed Tomography (SPECT). Thus, X-SPECT(tm) is capable of generating co-registered anatomical (CT) and functional (SPECT) maps of intact animals under anesthesia. This instrument will allow 9 NIH- funded investigators to complete and significantly improve their studies on drug development, staging of tumor progression, and monitoring of gene delivery efficacy. Importantly, the instrument will enable the investigators to complete longitudinal studies in vivo without sacrifice of experimental animals. Consequently, investigators will study fewer animals but get much more data from each animal. The X-SPECT(tm) imaging system is capable of imaging large number of single photon emitting radioisotopes that are readily available, such as 1-125 (30 keV), TI-201 (75 keV), 1-123 (159 keV), ln-111 (171, 250 keV) and 1-131 (364 keV). The capability to image 1-125 is of particular noteworthy as 1-125 is commonly used in ex vivo molecular biology studies to label nucleic acids, antibodies, and ligands in addition to various Pharmaceuticals. New Pharmaceuticals can also be iodinated relatively easily. With X-SPECT(tm), these studies can now be performed non-invasively in vivo. In addition, the X-SPECT(tm) imaging system can perform dual isotope imaging simultaneously, such that one may look at drug delivery and efficacy simultaneously using two different tracers. The use of pinhole collimator allows the spatial resolution for SPECT imaging less than 1 mm. The x-ray CT system achieves high resolution better than 100 ¿m. There is no similar instrument at the Ohio State University or other research centers in the State of Ohio. The instrument will be housed in a radioisotope certified laboratory animal facility in Wiseman Hall under the supervision of a research nuclear medicine technologist, who will work closely with the internal advisory committee. The principal investigator and the research nuclear medicine technologist have received training in the use of the A-SPECT(tm) imaging system (microSPECT component of the X-SPECT1 imaging system). Users will be trained by the principal investigator, the research nuclear medicine technologist, and laboratory animal veterinarian. The software will operate in a Window environment on a networked computer that will allow the investigators to access the data from distant sites. An hourly fee will provide funds for the annual service contract. The X-SPECT(tm) system will be integrated as a component of an Imaging Core Facility (shared resource). Thus, space and utilities for the instrument plus the salary and benefits for the research nuclear medicine technologist will be provided by the Ohio State University Comprehensive Cancer Center.

描述（由申请人提供）：本共享仪器拨款申请要求使用 Gamma Medica, Inc. 制造的 X-SPECT 成像系统。 X-SPECT(tm) 是一种双模态小动物成像系统，结合了 X 射线计算机断层扫描 (CT) 和单光子发射计算机断层扫描 (SPECT)。因此，X-SPECT(tm) 能够生成麻醉下完整动物的联合配准解剖 (CT) 和功能 (SPECT) 图。该仪器将使 9 名 NIH 资助的研究人员能够完成并显着改进他们在药物开发、肿瘤进展分期和基因传递功效监测方面的研究。重要的是，该仪器将使研究人员能够在不牺牲实验动物的情况下完成体内纵向研究。因此，研究人员将研究更少的动物，但从每只动物身上获得更多的数据。 X-SPECT(tm) 成像系统能够对大量现成的单光子发射放射性同位素进行成像，例如 1-125 (30 keV)、TI-201 (75 keV)、1-123 (159 keV)、ln-111 (171、250 keV) 和 1-131 (364 keV)。对 1-125 进行成像的能力尤其值得注意，因为 1-125 通常用于离体分子生物学研究中，以标记核酸、抗体和配体以及各种药物。新药品也可以相对容易地被碘化。借助 X-SPECT(tm)，这些研究现在可以在体内非侵入性地进行。此外，X-SPECT(tm) 成像系统可以同时进行双同位素成像，这样就可以使用两种不同的示踪剂同时观察药物输送和功效。针孔准直器的使用使得SPECT成像的空间分辨率小于1毫米。 X射线CT系统可实现优于100 µm的高分辨率。俄亥俄州立大学或俄亥俄州的其他研究中心没有类似的仪器。该仪器将安置在怀斯曼大厅经过放射性同位素认证的实验动物设施中，并由核医学研究技术专家监督，该技术专家将与内部咨询委员会密切合作。主要研究者和研究核医学技术专家接受过使用 A-SPECT(tm) 成像系统（X-SPECT1 成像系统的 microSPECT 组件）的培训。用户将接受首席研究员、核医学研究技术人员和实验动物兽医的培训。该软件将在联网计算机的 Windows 环境中运行，使调查人员能够从远程站点访问数据。按小时收费将为年度服务合同提供资金。 X-SPECT(tm) 系统将作为成像核心设施（共享资源）的一个组件进行集成。因此，仪器的空间和公用设施以及研究核医学技术专家的工资和福利将由俄亥俄州立大学综合癌症中心提供。