Comparative Toxicogenomics Database (CTD)

比较毒理基因组学数据库 (CTD)

• 批准号: 7089611
• 负责人: JAMES Lorenzen BOYER
• 金额: $ 80万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-18 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7089611
• 关键词: chemical information system; chemical structure function; data quality /integrity; disease /disorder etiology; environmental contamination; environmental exposure; environmental health; environmental toxicology; gene environment interaction; gene expression; information retrieval; literature citation; microarray technology; molecular biology information system; protein structure function; species difference; toxicology information system

DESCRIPTION (provided by applicant): The goal of this proposal is to establish an authoritative public database, the Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org), that promotes understanding about the effects of environmental chemicals on human health. The etiology of most chronic diseases involves interactions between environmental and genetic factors. Although more than 85,000 chemicals are used in commerce today, the complex molecular mechanisms underlying the actions of most of these chemicals and their effects on human health are poorly understood. In CTD we will present scientifically reviewed information on environmental chemicals, significant genes, and their interactions in vertebrates and invertebrates. The specific aims of this proposal are to: 1) curate and integrate chemical-gene interactions from published literature and high-throughput experimental data (e.g., microarrays); 2) curate cross-species toxicologically important genes and their proteins; and 3) transform the CTD prototype into a robust, production-quality database ready for increased public use and more sophisticated data search and analysis capabilities. CTD will be the first database to focus its curation on chemical-gene interactions and genes of toxicological significance in diverse species to elucidate structure-function correlations. These data will be key to building network models of chemical actions and providing important insights into differences in susceptibility to environmentally-induced toxicity and disease. Insights from CTD will also have important implications for toxicity prediction and environmental regulation. We are developing the publicly available Comparative Toxicogenomics Database (CTD) to promote understanding about the effects of environmental chemicals on human health. CTD will provide information on significant chemicals, genes, and their interactions in vertebrates and invertebrates. These data will provide important insights into the mechanisms of chemical actions and the genetic basis of differential toxicity among organisms and individuals, and will also have important implications for toxicity prediction and environmental regulation.

描述（由申请人提供）：本提案的目标是建立一个权威的公共数据库，即比较毒物基因组学数据库（CTD; http://ctd.mdibl.org），以促进对环境化学品对人类健康影响的了解。大多数慢性病的病因涉及环境和遗传因素之间的相互作用。尽管目前商业上使用的化学品超过85,000种，但人们对大多数化学品作用背后的复杂分子机制及其对人类健康的影响知之甚少。在CTD中，我们将介绍有关环境化学物质、重要基因及其在脊椎动物和无脊椎动物中的相互作用的科学综述信息。该提案的具体目标是：1)从已发表的文献和高通量实验数据（例如，微阵列）中整理和整合化学基因相互作用；2)整理跨物种毒理学重要基因及其蛋白；3)将CTD原型转换为一个强大的、生产质量的数据库，为公众使用和更复杂的数据搜索和分析能力做好准备。CTD将是第一个将其管理重点放在不同物种的化学-基因相互作用和毒理学意义基因上，以阐明结构-功能相关性的数据库。这些数据将是建立化学作用网络模型的关键，并提供对环境引起的毒性和疾病的易感性差异的重要见解。CTD的见解也将对毒性预测和环境监管产生重要影响。我们正在开发可公开使用的比较毒物基因组学数据库（CTD），以促进对环境化学品对人类健康影响的了解。CTD将提供有关脊椎动物和无脊椎动物中重要的化学物质、基因及其相互作用的信息。这些数据将为生物和个体之间的化学作用机制和差异毒性的遗传基础提供重要见解，并将对毒性预测和环境调节具有重要意义。