Prenatal MF Exposure & Miscarriage Risk Among Women

产前 MF 暴露

• 批准号: 7013142
• 负责人: De-Kun Li
• 金额: $ 62.98万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7013142
• 关键词: adult human (21+); biomagnetism measurement; chronic disease /disorder; chronic spontaneous abortion; clinical research; disease /disorder proneness /risk; environmental exposure; epidemiology; female; fertility; gestational age; human pregnant subject; interview; magnetic field; personal log /diary; public health; spontaneous abortion; women' s health

DESCRIPTION (provided by applicant): Two recently published papers have raised concerns about exposure to high levels >=16 milligauss (mG)] of magnetic fields (MFs) during pregnancy and the risk of miscarriage. Power frequency MFs are ubiquitous and about 75% of pregnant women were exposed to MF levels >=16 mG. Therefore, if the reported association of prenatal exposure to MFs >=16 mG with the risk of miscarriage (relative risk ranging from 1.8 to 5.7) is true, it will have significant public health implications. To further examine this association, we propose to conduct a population-based prospective cohort study among susceptible and non-susceptible pregnant women. We will over-sample susceptible women defined as having a history of multiple miscarriages. As demonstrated in our preliminary study, a MF effect on miscarriage is greater among susceptible women than among the overall pregnant population. Further evaluating the MF-miscarriage association among both susceptible and nonsusceptible women has the advantage of increasing the sensitivity of detecting a MF effect and providing an opportunity to compare the difference in the magnitude of the MF effect. The study will be conducted among members of the Kaiser Permanente Medical Care Program Northern California Region, a group-model integrated healthcare delivery system with 32,000 births each year. We will recruit a total of 1,000 pregnant women: 500 with a history of multiple miscarriages and 500 without such a history. In-person interviews will be conducted to collect information on known risk factors for miscarriage. Participants will be asked to wear a meter for 24 hours to capture their personal MF exposure from all sources and to keep a diary of her activities. Pregnancy outcomes will be ascertained through a combination of searching computerized databases, review of medical charts, and telephone follow-up. The Cox proportional hazard regression will be used to determine (a) whether exposure to MF levels =>16 mG during pregnancy increases the risk of miscarriage, (b) whether there is a dose-response relationship, (c) whether this association is stronger for early miscarriage (< 10 weeks of gestation), and (d) whether this association differs between women with and without a history of multiple miscarriages. The proposed study will also significantly improve MF exposure measurements including an enhanced meter capability, repeat measurements, identifying sources of high MF exposure, and measurements on a typical day. Our experience and expertise gained from the recently completed study of MF-miscarriage association should provide significant assurance for the success of the proposed study. The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect.

描述(由申请人提供)：最近发表的两篇论文提出了对怀孕期间暴露于高水平磁场(MFS)和流产风险的担忧。工频MFS无处不在，大约75%的孕妇暴露在&Gt；=16毫克的Mf水平下。因此，如果报告的产前接触MFS和Gt；=16毫克与流产风险(相对风险从1.8到5.7)之间的关联是真实的，它将对公共卫生产生重大影响。为了进一步研究这种关联，我们建议在易感和非易感孕妇中进行一项基于人群的前瞻性队列研究。我们将对被定义为有多次流产史的易感女性进行过度抽样。正如我们的初步研究表明，在易感流产的妇女中，MF对流产的影响比在整个怀孕人群中更大。进一步评估易感和非易感妇女之间的胎膜早产-流产相关性具有提高检测胎膜早破效应的敏感性，并提供机会比较孕囊效应的大小差异的优势。这项研究将在凯撒永久医疗保健计划北加州地区的成员中进行，该计划是一个团体模式的综合医疗保健提供系统，每年有3.2万名新生儿出生。我们将招募1000名孕妇：500名有多次流产史，500名没有这样的病史。将进行面谈，以收集有关流产的已知风险因素的信息。参与者将被要求佩戴仪表24小时，以记录他们从所有来源获得的个人MF接触情况，并记录她的活动日记。妊娠结局将通过搜索计算机数据库、查看病历和电话随访相结合来确定。考克斯比例风险回归将被用来确定：(A)怀孕期间暴露于MF水平=16毫克是否会增加流产的风险，(B)是否存在剂量-反应关系，(C)这种联系在早期流产(怀孕10周)是否更强，以及(D)这种联系在有多次流产史和没有多次流产史的妇女之间是否有所不同。拟议的研究还将显著改进MF暴露测量，包括增强的计量器能力、重复测量、识别高MF暴露的来源以及典型日期的测量。我们从最近完成的胎膜早产-流产相关性研究中获得的经验和专业知识应为拟议研究的成功提供重要保证。这项拟议研究的结果将为最近报道的结果提供亟需的证实，并促进我们对MF健康影响的理解。