Prenatal MF Exposure & Miscarriage Risk Among Women

产前 MF 暴露

• 批准号: 7339336
• 负责人: De-Kun Li
• 金额: $ 60.62万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339336
• 关键词: Age; Biological; Birth; California; Caring; Characteristics; Cohort Studies; Confidence Intervals; Databases; Disease regression; Doctor of Philosophy; Dose; Environmental Risk Factor; Exposure to; Frequencies; Health; Hour; Intervention; Interview; Knowledge; Link; Measurement; Measures; Medical; Modeling; Nature; Numbers; Paper; Participant; Patient currently pregnant; Persons; Population; Population Programs; Population Study; Positioning Attribute; Pregnancy; Pregnancy Outcome; Pregnant Women; Public Health; Publishing; Range; Recording of previous events; Recruitment Activity; Relative Risks; Reporting; Research Design; Rest; Risk; Risk Factors; Sampling; Source; Spontaneous abortion; Study of magnetics; System; Telephone; Time; Week; Weight; Woman; base; computerized; cost; day; design; diaries; experience; follow-up; hazard; health care delivery; improved; innovation; magnetic field; member; meter; prenatal; prenatal exposure; programs; prospective; response; success

DESCRIPTION (provided by applicant): Two recently published papers have raised concerns about exposure to high levels >=16 milligauss (mG)] of magnetic fields (MFs) during pregnancy and the risk of miscarriage. Power frequency MFs are ubiquitous and about 75% of pregnant women were exposed to MF levels >=16 mG. Therefore, if the reported association of prenatal exposure to MFs >=16 mG with the risk of miscarriage (relative risk ranging from 1.8 to 5.7) is true, it will have significant public health implications. To further examine this association, we propose to conduct a population-based prospective cohort study among susceptible and non-susceptible pregnant women. We will over-sample susceptible women defined as having a history of multiple miscarriages. As demonstrated in our preliminary study, a MF effect on miscarriage is greater among susceptible women than among the overall pregnant population. Further evaluating the MF-miscarriage association among both susceptible and nonsusceptible women has the advantage of increasing the sensitivity of detecting a MF effect and providing an opportunity to compare the difference in the magnitude of the MF effect. The study will be conducted among members of the Kaiser Permanente Medical Care Program Northern California Region, a group-model integrated healthcare delivery system with 32,000 births each year. We will recruit a total of 1,000 pregnant women: 500 with a history of multiple miscarriages and 500 without such a history. In-person interviews will be conducted to collect information on known risk factors for miscarriage. Participants will be asked to wear a meter for 24 hours to capture their personal MF exposure from all sources and to keep a diary of her activities. Pregnancy outcomes will be ascertained through a combination of searching computerized databases, review of medical charts, and telephone follow-up. The Cox proportional hazard regression will be used to determine (a) whether exposure to MF levels =>16 mG during pregnancy increases the risk of miscarriage, (b) whether there is a dose-response relationship, (c) whether this association is stronger for early miscarriage (< 10 weeks of gestation), and (d) whether this association differs between women with and without a history of multiple miscarriages. The proposed study will also significantly improve MF exposure measurements including an enhanced meter capability, repeat measurements, identifying sources of high MF exposure, and measurements on a typical day. Our experience and expertise gained from the recently completed study of MF-miscarriage association should provide significant assurance for the success of the proposed study. The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect.

描述（由申请人提供）：最近发表的两篇论文引起了人们对怀孕期间暴露于>=16毫高斯（mG）的高水平磁场（MF）和流产风险的担忧。工频MF普遍存在，约75%的孕妇暴露于>=16 mG的MF水平。因此，如果报告的产前暴露于大于等于16 mG的MF与流产风险（相对风险范围为1.8至5.7）之间的关联是真实的，则将具有重大的公共卫生影响。为了进一步研究这种关联，我们建议在易感和非易感孕妇中进行一项基于人群的前瞻性队列研究。我们将对定义为有多次流产史的易感女性进行过度抽样。正如我们的初步研究所示，MF对流产的影响在易感妇女中比在整个怀孕人群中更大。进一步评估易感和非易感妇女之间的MF-流产关联具有增加检测MF效应的灵敏度并提供比较MF效应大小差异的机会的优点。该研究将在Kaiser Permanente医疗保健计划北方加州地区的成员中进行，该计划是一个每年有32，000名新生儿的群体模式综合医疗保健提供系统。我们将招募总共1，000名孕妇：500名有多次流产史，500名没有此类历史。将进行面对面访谈，以收集有关流产的已知风险因素的信息。参与者将被要求佩戴测量仪24小时，以从所有来源记录其个人MF暴露，并记录其活动日记。将通过计算机数据库检索、病历审查和电话随访相结合来确定妊娠结局。将使用考克斯比例风险回归确定（a）妊娠期间暴露于MF水平≥ 16 mG是否会增加流产风险，（B）是否存在剂量-反应关系，（c）这种关联是否与早期流产（< 10孕周）有关，以及（d）这种关联是否在有和无多次流产史的女性之间存在差异。拟议的研究还将显著改善MF暴露测量，包括增强的仪表能力、重复测量、确定高MF暴露源以及典型日的测量。我们从最近完成的MF-流产相关性研究中获得的经验和专业知识应为拟议研究的成功提供重要保证。这项研究的结果将为最近报道的结果提供急需的证实，并促进我们对MF健康影响的理解。