Human Handedness Psychosis Etiology Studies

人类惯用手精神病病因学研究

• 批准号: 7291767
• 负责人: AMAR J KLAR
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7291767
• 关键词: Human; Handedness; Psychosis; Etiology; Studies

Ninety-seven per cent of right-handed (RH) individuals develop speech and language processing in the left (dominant) hemisphere of the brain, while the "minor" hemisphere controls emotional behavior. However, this correlation fails in LH (left-handed) individuals; 70% are left-brain dominant and 30% are right-brain dominant. The reason for this complex correlation of handedness with brain lateralization has been the key unanswered question for brain development. We have speculated that a hypothetical gene, RGHT, functions to specify left-brain dominance resulting in developing the right-handed preference. To test these ideas experimentally, we have been collecting blood samples and cheek swabs from specific families with the aim to genetically map the hypothesized RGHT gene. We have collected enough samples and the next stage is to use these samples for mapping by the sib-pair method. We have published our random recessive model in which individuals with the nonfunctional recessive allele on both homologs have a 50:50 chance of either being RH or LH. Recently, we found interesting association of hand use preference with the clockwise vs. counterclockwise scalp hair-whorl rotation. We suggest that individuals with the right gene are RH and develop clockwise hair whorls, but individuals with the recessive allele are 50:50 in hair whorl orientation.

97%的右撇子（RH）个体在大脑的左半球（主导）开发语音和语言处理，而“次要”半球控制情感行为。然而，这种相关性在LH（左撇子）个体中失败了; 70%的人是左脑主导型，30%是右脑主导型。惯用手与大脑侧化之间复杂的相关性的原因一直是大脑发育中未回答的关键问题。我们推测，一个假设的基因，RGHT，功能指定左脑优势，导致发展右手偏好。为了通过实验来验证这些想法，我们一直在收集特定家庭的血液样本和脸颊拭子，目的是对假设的RGHT基因进行遗传作图。我们已经收集了足够的样本，下一阶段是使用这些样本通过同胞配对方法进行映射。我们已经发表了我们的随机隐性模型，其中两个同系物上都有非功能性隐性等位基因的个体有50：50的机会成为RH或LH。最近，我们发现有趣的关联，手的使用偏好与顺时针和逆时针头皮发旋旋转。我们认为，个体与正确的基因是RH和发展顺时针发旋，但个体与隐性等位基因是50：50的发旋方向。