HUMAN HANDEDNESS STUDIES

97%的右撇子（RH）在大脑的左半球（主导）发展语言和语言处理，而小半球控制情绪行为。然而，这种相关性在LH（左撇子）个体中不存在；70%的人左脑占优势，30%的人右脑占优势。利手性与大脑侧化的复杂关联的原因一直是大脑发育的关键未解问题。我们推测，一个假设的基因，右，功能指定左脑优势，导致发展右手偏好。为了从实验上验证这些想法，我们一直在收集特定家庭的血液样本和脸颊拭子，目的是绘制假设的正确基因的基因图谱。我们已经收集了足够的样本，下一阶段是使用这些样本通过兄弟对方法进行映射。我们已经发表了我们的随机隐性模型，在该模型中，在两个同源物上具有非功能性隐性等位基因的个体有50:50的机会成为RH或LH。

Ninety-seven per cent of right-handed (RH) individuals develop speech and language processing in the left (dominant) hemisphere of the brain, while the minor hemisphere controls emotional behavior. However, this correlation fails in LH (left-handed) individuals; 70% are left-brain dominant and 30% are right-brain dominant. The reason for this complex correlation of handedness with brain lateralization has been the key unanswered question for brain development. We have speculated that a hypothetical gene, RGHT, functions to specify left-brain dominance resulting in developing the right-handed preference. To test these ideas experimentally, we have been collecting blood samples and cheek swabs from specific families with the aim to genetically map the hypothesized RGHT gene. We have collected enough samples and the next stage is to use these samples for mapping by the sib-pair method. We have published our random recessive model in which individuals with the nonfunctional recessive allele on both homologs have a 50:50 chance of either being RH or LH.