Longitudinal Assessment of Manic Symptoms

躁狂症状的纵向评估

• 批准号: 7286320
• 负责人: ROBERT L FINDLING
• 金额: $ 81.35万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-16 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286320
• 关键词: Academic Medical Centers; Achievement; Adolescent; Age; Ambulatory Care; Antidepressive Agents; Attention deficit hyperactivity disorder; Behavior; Bipolar Disorder; Caring; Characteristics; Child; Childhood; Clinic; Clinical; Comorbidity; Condition; Conduct Disorder; DSM-IV; Data; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Differential Diagnosis; Disease; Drug usage; Environment; Equipment and supply inventories; Event; Evolution; Exposure to; Family; Family history of; Functional disorder; Genetic; Individual; Institutes; Intake; Life; Literature; Longitudinal Studies; Manic; Measures; Mental Depression; Mental Health; Mental disorders; Moods; Numbers; Ohio; Outcome; Outpatients; Parents; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Phenotype; Prevalence; Psychiatric therapeutic procedure; Psychopathology; Puberty; Publishing; Rate; Recruitment Activity; Research; Risk-Taking; Sampling; Schools; Score; Screening procedure; Site; Symptoms; Time; Universities; University Hospitals; Work; Youth; base; clinical Diagnosis; cohort; disease classification; falls; follow-up; functional outcomes; innovation; prospective; psychosocial; response; stem; stressor

Pediatric bipolar disorder (PBD) is a spectrum of serious psychiatric disorders with considerable controversy surrounding its clinical presentation, course, and treatment response prior to puberty. Unfortunately there are substantial problems associated with accurately identifying these disorders in children. These difficulties stem from the overlap of the symptoms of PBD with other common conditions (such as ADHD, depression and conduct disorder) as well as the lack of prospective longitudinal studies of the differential symptomatology, treatment response and functioning of children selected for the hallmark feature of bipolarity, elevated symptoms of mania (ESM). There is a growing body of scientific evidence that a large number of children who are brought to psychiatric care have ESM. Some of these children meet strict DSM- IV criteria for the prototypic bipolar disorders, bipolar 1 (BP1) or bipolar 2 (BP2) disorder. However, a substantial number of children with ESM do not meet DSM criteria for either BP1 or BP2. Regardless of their working diagnosis at the time of assessment, children with ESM suffer from high degrees of psychopathology and from pronounced psychosocial dysfunction. Furthermore, the limited and dated follow- up data available suggests that many children with ESM do not develop bipolar disorders over time. Regrettably, very little is known about the phenomenology, course, or symptomatic evolution of youngsters who present with ESM. The "Longitudinal Assessment of Manic Symptoms" (LAMS) study is a collaborative, multi-site R01 that proposes to carefully investigate ESM in children and adolescents. The proposed project would be conducted at four sites over five years: Case Western Reserve University/University Hospitals of Cleveland (Case/UHC), Western Psychiatric Institute and Clinic (WPIC), Cincinnati Children's Hospital Medical Center/University of Cincinnati (CCHMC/UC), and Ohio State University. LAMS proposes the innovative step of screening a large sample of children who present for care with ESM, regardless of their clinical diagnoses, and carefully examining them both cross-sectionally and over time. LAMS will advance the field by providing the data necessary to develop valid, evidence-based criteria for a childhood-specific bipolar phenotype. The proposed research will also lend clarification to current controversies regarding the differential diagnosis between bipolar spectrum disorders and ADHD in children.

儿童双相情感障碍(PBD)是一种严重的精神障碍，有相当大的争议 围绕其临床表现、病程和青春期前的治疗反应。不幸的是，有 与准确识别儿童的这些障碍相关的实质性问题。这些困难 源于PBD的症状与其他常见疾病(如ADHD、抑郁症)的重叠 和品行障碍)，以及缺乏对差异的前瞻性纵向研究 儿童的症状学、治疗反应和功能 两极，躁狂症状升高(ESM)。越来越多的科学证据表明， 被带到精神科护理的儿童中有许多患有ESM。其中一些孩子符合严格的DSM- 典型双相障碍的IV标准，即双相1(BP1)或双相2(BP2)。然而，a 大量患有ESM的儿童不符合BP1或BP2的DSM标准。不管他们的 在评估工作诊断时，患有ESM的儿童患有高度的 精神病理学和明显的心理社会功能障碍。此外，有限的和日期的跟踪- 可获得的UP数据表明，许多患有ESM的儿童不会随着时间的推移而患上双相情感障碍。 遗憾的是，人们对青少年的现象学、病程或症状演变知之甚少。 他们与ESM一起出席。“躁狂症状纵向评估”(LAMS)研究是一项合作研究， 多站点R01，建议仔细研究儿童和青少年的ESM。拟议中的项目 将在五年内在四个地点进行：凯斯西储大学/华盛顿大学医院 克利夫兰(病例/UHC)，西方精神病研究所和诊所(WPIC)，辛辛那提儿童医院 医学中心/辛辛那提大学(CCHMC/UC)和俄亥俄州立大学。LAMS建议 对接受ESM护理的儿童进行大样本筛查的创新步骤，无论他们 临床诊断，并仔细检查他们的横断面和随时间推移。LAMS将取得进展 通过提供必要的数据，为儿童特殊情况制定有效的、基于证据的标准 两极表型。拟议的研究也将澄清目前关于 儿童双相情感障碍与多动症的鉴别诊断。