Biomarkers of Insomnia and Fatigue in HIV/AIDS

艾滋病毒/艾滋病中失眠和疲劳的生物标志物

• 批准号: 7265173
• 负责人: KATHRYN LEE
• 金额: $ 49.74万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7265173
• 关键词: AIDS/HIV problem; Adherence; Adult; Adverse effects; Affect; Alternative Therapies; Anemia; Biological Markers; CD4 Lymphocyte Count; Chronic Disease; Clinical Trials; Cognitive Therapy; Complex; Daily; Data; Dimensions; Disease; Dose; Fatigue; Genes; Genetic Determinism; Genetic Polymorphism; Glucose; HIV; HIV Infections; Hemoglobin; Human Genome Project; Insulin; Intervention; Israel; Leptin; Life; Lipodystrophy; Maintenance; Measures; Medical; Metabolic; Middle Insomnia; Napping; Nonesterified Fatty Acids; Parents; Patients; Performance at work; Persons; Pharmaceutical Preparations; Phase; Polysomnography; Productivity; Purpose; Quality of life; Reporting; Research; Research Personnel; Rest; Role; Sampling; Schedule; Self Perception; Severities; Sleep; Sleep disturbances; Sleeplessness; Symptoms; Testing; Time; Viral Load result; Woman; Work; actigraphy; adiponectin; alertness; cognitive function; day; depressive symptoms; experience; falls; hypnotic; improved; medication compliance; men; morin; pill; sleep onset; social

DESCRIPTION (provided by applicant): The purpose of this proposed study is to characterize the experience of subtypes of insomnia (initiation, maintenance, and daytime fatigue or sleepiness) in HIV-infected persons, and to identify biomarkers associated with these subtypes such that a more targeted intervention can be developed and tested to improve sleep, reduce fatigue, and thereby enhance quality of life in HIV-seropositive men and women. In Phase I, descriptive data will be gathered on a cross-sectional sample of 250 or more subjects in year 01-02 to identify relationships between insomnia subtypes and selected biomarkers. In Phase II, longitudinal data will be gathered on up to 100 men and 100 women, asymptomatic at Time 1, to characterize insomnia subtypes as they develop over time. There are four aims: 1) test relationships between objective sleep disturbance (wake/sleep rhythm, total sleep time day and night, wake after sleep onset) and common gene polymorphisms, selected metabolic parameters (insulin, glucose, adiponectin, leptin, free fatty acids), HIV severity indicators (viral load, CD4 cell count), anthropometric measures of lipodystrophy, and quality of life (fatigue, cognitive function, depressive symptoms) for both men and women who are HIV-seropositive; 2) test relationships between subjective sleep disturbances (time to fall asleep, awakenings) and gene polymorphisms, metabolic parameters, HIV indicators, anthropometrics, and quality of life for both men and women; 3) describe onset of symptoms and medication adherence over time in initially asymptomatic subjects who are HIV-seropositive; and 4) test which sets of variables significant in Aim 1 and Aim 2 best predict the onset of insomnia subtypes. It is hypothesized that the set of biomarkers that best predict the onset of initiation insomnia may differ from the variables that predict maintenance insomnia or daytime quality of life measures.

描述（由申请人提供）： 这项拟议研究的目的是描述 HIV 感染者失眠亚型（起始、维持和白天疲劳或嗜睡）的经历，并确定与这些亚型相关的生物标志物，以便开发和测试更有针对性的干预措施，以改善睡眠、减少疲劳，从而提高 HIV 血清阳性男性和女性的生活质量。 在第一阶段，将在 01-02 年收集 250 名或更多受试者的横断面样本的描述性数据，以确定失眠亚型和选定的生物标志物之间的关系。 在第二阶段，将收集最多 100 名男性和 100 名女性（在时间 1 时无症状）的纵向数据，以描述失眠亚型随着时间的推移而发展的特征。 有四个目标：1) 测试客观睡眠障碍（觉醒/睡眠节律、白天和晚上的总睡眠时间、入睡后觉醒）与常见基因多态性、选定的代谢参数（胰岛素、葡萄糖、脂联素、瘦素、游离脂肪酸）、HIV 严重程度指标（病毒载量、CD4 细胞计数）、脂肪营养不良的人体测量指标和生活质量之间的关系 （疲劳、认知功能、抑郁症状）针对艾滋病毒血清阳性的男性和女性； 2）测试男性和女性主观睡眠障碍（入睡时间、觉醒时间）与基因多态性、代谢参数、HIV指标、人体测量学和生活质量之间的关系； 3) 描述 HIV 血清阳性的最初无症状受试者随时间的症状发作和药物依从性； 4) 测试目标 1 和目标 2 中哪些显着变量组最能预测失眠亚型的发作。 据推测，最能预测起始失眠发生的一组生物标志物可能不同于预测维持性失眠或日间生活质量测量的变量。

项目成果

Psychometric Limitations of the Center for Epidemiologic Studies-Depression Scale for Assessing Depressive Symptoms among Adults with HIV/AIDS: A Rasch Analysis.

• DOI: 10.1155/2016/2824595
• 发表时间: 2016-01-01
• 期刊: Depression research and treatment
• 作者: Gay, Caryl L;Kottorp, Anders;Lee, Kathryn A
• 通讯作者: Lee, Kathryn A

Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults.

人类免疫缺陷病毒感染成人的代谢异常和冠心病风险。

• DOI: 10.1089/met.2009.0094
• 发表时间: 2010
• 期刊: Metabolic syndrome and related disorders
• 影响因子: 2.1
• 作者: Pullinger,CliveR;Aouizerat,BradleyE;Gay,Caryl;Coggins,Traci;Movsesyan,Irina;Davis,Harvey;Kane,JohnP;Portillo,Carmen;Lee,KathrynA
• 通讯作者: Lee,KathrynA

Can the Fatigue Severity Scale 7-item version be used across different patient populations as a generic fatigue measure--a comparative study using a Rasch model approach.

• DOI: 10.1186/1477-7525-12-24
• 发表时间: 2014-02-22
• 期刊: Health and quality of life outcomes
• 影响因子: 3.6
• 作者: Johansson S;Kottorp A;Lee KA;Gay CL;Lerdal A
• 通讯作者: Lerdal A

Self-reported medication adherence and symptom experience in adults with HIV.

• DOI: 10.1016/j.jana.2010.11.004
• 发表时间: 2011-07
• 期刊: JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
• 影响因子: 2
• 作者: Gay, Caryl;Portillo, Carmen J.;Kelly, Ryan;Coggins, Traci;Davis, Harvey;Aouizerat, Bradley E.;Pullinger, Clive R.;Lee, Kathryn A.
• 通讯作者: Lee, Kathryn A.

Cytokine polymorphisms are associated with fatigue in adults living with HIV/AIDS.

• DOI: 10.1016/j.bbi.2014.02.017
• 发表时间: 2014-08
• 期刊: BRAIN BEHAVIOR AND IMMUNITY
• 影响因子: 15.1
• 作者: Lee, Kathryn A.;Gay, Caryl L.;Lerdal, Anners;Pullinger, Clive R.;Aouizerat, Bradley E.
• 通讯作者: Aouizerat, Bradley E.