The Quantification of Orthotic interventions in Osteoarthritic Knee Instability (QOOKI)

这个项目旨在开发和验证一种明确、客观的测量方法来量化和诊断膝关节不稳定，该方法易于在临床上收集。我们认为惯性测量单元(IMU)技术在这种情况下是最合适的。由于不稳定人群的普遍存在，我们将重点放在OA人群上，但目标是更广泛地应用于其他健康的膝盖和TKA膝盖。为了达到上述目的，我们将使用软支撑和卸载支撑来影响膝关节运动学，以验证客观测量并确定每种支撑的有效性。在这样做的过程中，我们将确定那些最有可能从矫形手术中受益的人的膝部特征。我们还旨在通过适当调整支架，根据我们开发的测量方法，将参与者分组和分类到不同的组(即，机械或神经)，从而解决关于个人主观不稳定是否由机械性或本体感觉缺陷引起的争论。

Project DescriptionThis project aims to develop and validate an unambiguous, objective measure to quantify and diagnose knee instability which can easily be collected in the clinic. We believe inertial measurement unit (IMU) technology to be most appropriate in this context. We shall focus on the OA population due to the prevalence of instability in this population, but the aim has a wider application to both otherwise healthy and TKA knees. To achieve the above aim, we shall affect knee kinematics using both soft and unloading knee braces to both validate the objective measure and to ascertain the effectiveness of each type of brace. In doing so, we will identify the characteristic knee signatures of those most likely to benefit from orthotic intervention. We also aim to disentangle the debate regarding whether an individual's subjective instability has a mechanical or proprioceptive-deficit cause by suitable adjustment of the braces enabling the clustering and categorising of participants into different groups (i.e. mechanical or neurological) based on our developed measure.