How does knee joint and meniscal tissue shape affect joint biomechanics and treatment choice?
膝关节和半月板组织形状如何影响关节生物力学和治疗选择?
基本信息
- 批准号:2883829
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Over 4.5 million people in the UK have knee arthritis. Damage to the meniscus tissue, at the centre of the knee joint, can be both a cause and symptom of knee osteoarthritis. However, successful treatment remains elusive, partly due to variations in knee anatomy and function. This PhD will build on the novel experimental and computational methods developed at the University of Leeds to examine how meniscal repair or replacement surgery can be better matched to patient characteristics. Methods will include: finite element modelling of the joint under physiologically relevant conditions; statistical shape modelling to explore how knee function alters with variations in bone and meniscus shape; and experimental evaluation of meniscal tissue and allografts. Aim and objectives The aim of this PhD is to examine how meniscal repair or replacement surgery can be better matched to patient characteristics. Using a combination of experimental and computational methods, the objectives are: -To characterize the changes in shape and properties of meniscal tissue using imaging and in vitro testing methods -To examine how these changes affect knee kinematics using image-based finite element models of the natural knee -To explore the use of statistical shape and appearance models to represent variations in the population and examine the match required for meniscal surgery to restore individual biomechanical function
英国有超过450万人患有膝关节关节炎。膝关节中心半月板组织的损伤既可能是膝关节骨关节炎的原因,也可能是其症状。然而,成功的治疗仍然难以捉摸,部分原因是膝关节解剖结构和功能的变化。该博士学位将以利兹大学开发的新颖实验和计算方法为基础,研究半月板修复或置换手术如何更好地与患者特征相匹配。方法将包括:关节在生理相关条件下的有限元建模;统计形状建模,探讨膝关节功能如何随着骨骼和半月板形状的变化而改变;半月板组织和同种异体移植的实验评价。目的和目的本博士的目的是研究半月板修复或置换手术如何更好地与患者的特点相匹配。采用实验与计算相结合的方法,目标是:-使用成像和体外测试方法表征半月板组织形状和特性的变化-使用基于图像的自然膝关节有限元模型检查这些变化如何影响膝关节运动学-探索使用统计形状和外观模型来表示人群的变化,并检查半月板手术恢复个体生物力学功能所需的匹配
项目成果
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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