Does low dose amitriptyline reduce pain in knee osteoarthritis? A double blind, randomised, pragmatic, placebo controlled clinical trial of amitriptyline in addition to usual care
Does low dose amitriptyline reduce pain in knee osteoarthritis? A double blind, randomised, pragmatic, placebo controlled clinical trial of amitriptyline in addition to usual care
批准号:
nhmrc : 1083664
负责人:
A/Pr Anita Wluka
金额:
$27.59万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.
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