Does low dose amitriptyline reduce pain in knee osteoarthritis? A double blind, randomised, pragmatic, placebo controlled clinical trial of amitriptyline in addition to usual care

小剂量阿米替林可以减轻膝骨关节炎的疼痛吗？

• 批准号: nhmrc : 1083664
• 负责人: A/Pr Anita Wluka
• 金额: $ 27.59万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-low-dose-usual-care/518949
• 关键词: Does; low; dose; amitriptyline; reduce

Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.

疼痛是骨关节炎患者的主要问题，骨关节炎是关节炎的一种常见形式。这种疼痛没有得到很好的控制。疼痛来自关节的结构变化。然而，经过一段时间，有些人由于神经系统的变化而产生疼痛，称为疼痛敏感化。这不受常规治疗的影响。阿米替林用于治疗疼痛敏感。这项研究是一项随机试验，旨在观察阿米替林是否能在3个月内缓解膝关节骨关节炎患者的疼痛。