Does statin use have a disease modifying effect in symptomatic knee osteoarthritis?

使用他汀类药物对有症状的膝骨关节炎有改善疾病的作用吗？

• 批准号: nhmrc : 1074979
• 金额: $ 8.88万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-statin-use-knee-osteoarthritis/455640
• 关键词: Does; statin; use; disease; modifying

Osteoarthritis (OA) is a major cause of knee pain and disability. Treatments are limited to reducing pain and improving function: no therapy slows disease progression, with symptomatic end-stage OA treated by knee replacement. Statins, a drug class used to lower cholesterol levels, may affect the structural progression in knee OA. We propose a randomised controlled trial to see if statin use slows the progression of knee OA, which would delay or prevent the need for joint replacement.

骨关节炎（OA）是膝关节疼痛和残疾的主要原因。治疗仅限于减轻疼痛和改善功能：没有任何治疗可以减缓疾病进展，症状性终末期OA通过膝关节置换术治疗。他汀类药物是一种用于降低胆固醇水平的药物，可能会影响膝关节OA的结构进展。我们提出了一项随机对照试验，看看他汀类药物的使用是否会减缓膝关节OA的进展，这将延迟或防止关节置换的需要。