Exploring the role of vascular perfusion in the development of deep tissue injury during transtibial prosthetic use

项目描述本项目将通过数学和计算方法研究经胫骨假体使用者中血管灌注在深部组织损伤发展中的作用。特别是，它的目的是开发一维一维模型的血液动力学环境中的残肢transtibial截肢者研究截肢后的速度，压力和壁面剪切应力分布的修改，并与健康的血管系统相比。它的进一步目标是开发经胫骨截肢者的残肢的软组织变形的三维3D模型，将流体压力和考虑到外部负载。该项目还将研究血管系统如何能够重塑。

Project Description This project will investigate the role of vascular perfusion in deep tissue injury development in transtibial prosthetic users via mathematical and computational methods. In particular, it aims to develop one-dimensional 1D models of the haemodynamics environment in the residual limb of transtibial amputees to study the velocity, pressure, and wall shear stress distribution modifications post-amputation and in comparison with the healthy vasculature. It further aims to develop three dimensional 3D models of the soft tissue deformation of the residual limb of transtibial amputees, incorporating the fluid pressure and taking into account external loads. The project will also investigate how the vascular system is able to remodel.