Model systems for exchange of liquid between different aerosol sources: application in disease risk during aerosol therapies

不同气溶胶源之间液体交换的模型系统：在气溶胶治疗期间疾病风险中的应用

• 批准号: 2885381
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885381
• 关键词: Model; systems; exchange; liquid; between

The aim of this project is to assess processes whereby aerosol droplets can pick up components of another liquid from interaction either with a second aerosol stream or with a liquid surface. The process is of interest to the industrial partner in order to understand whether it is plausible that such a mechanism could produce additional infectious aerosol (for example, due to COVID infection in the patient) during nebuliser-based therapy. These are fundamental scientific questions, and to address them aspects of the physics and chemistry of aerosols need to be combined with the biology of respiratory infections. Specifically, this question requires modelling and experiments on the transport of liquids between droplets during aerosol mixing and on the deposition of therapeutic aerosols on airway surfaces. These questions are of tremendous importance to industry, especially in developing safe pharmaceutical aerosol therapies. Previously, a lack of scientific understanding in this area has resulted in misleading guidance with regards to the relative safety of aerosol therapies to other patients and healthcare providers.

该项目的目的是评估气溶胶液滴可以通过与第二个气溶胶气流或与液体表面的相互作用吸收另一种液体的成分的过程。工业伙伴对这一过程感兴趣，以便了解这种机制是否可能在基于雾化器的治疗期间产生额外的感染性气雾剂(例如，由于患者的COVID感染)。这些都是基本的科学问题，要解决这些问题，气雾剂的物理和化学方面需要与呼吸道感染的生物学相结合。具体地说，这个问题需要对气雾剂混合过程中液滴之间的液体传输和治疗性气雾剂在呼吸道表面的沉积进行建模和实验。这些问题对工业非常重要，特别是在开发安全的药物气雾剂疗法方面。此前，在这一领域缺乏科学理解导致了关于气雾剂疗法对其他患者和医疗保健提供者的相对安全性的误导性指导。