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ZFIN: The Zebrafish Model Organism Database

ZFIN：斑马鱼模式生物数据库

基本信息

批准号：
10369589
负责人：
Monte Westerfield
金额：
$ 211.2万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-11 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10369589
关键词：
Adopted Affect Animal Model Antisense Oligonucleotides Base Sequence Behavior Biological Biomedical Research Code Communities Computer software Data Data Science Data Set Databases Development Disease Elements Evolution FAIR principles Gene Expression Generations Genes Genetic Genetic Models Genome Genomics Goals Guidelines Human Human Biology Human Genome Individual Industry Standard Information Networks Infrastructure International Laboratories Link Metadata Modeling Mutate Mutation Nomenclature Organism Organogenesis Orthologous Gene Other Genetics Pattern Phenotype Physiological Physiology Play Process Proteins Publications Readability Recovery Research Research Activity Research Personnel Resources Role Site Societies Software Tools Strategic Planning Structure Surveys Techniques Technology Training Transgenic Organisms United States National Institutes of Health Update Vertebrate Biology Vertebrates Visualization Work Zebrafish data access data curation data exchange data management data resource gene function genetic analysis genome analysis genome editing genome resource human disease human model improved insight knock-down knockout gene meetings model organisms databases outreach public database reference genome repository software systems symposium time use tool user centered design web site wiki

项目摘要

Discovering the functions of the tens of thousands of genes in the human genome is a required step for understanding human biology and disease. Genetic model organisms, including zebrafish, play a critical role in this discovery process, because genetic analysis can connect gene sequence and function. Model organism databases, like ZFIN, provide tools required to make this connection. The zebrafish has emerged as a premier organism to study vertebrate biology. Powerful techniques allow rapid efficient generation and recovery of mutations affecting genes that orchestrate developmental patterning, organogenesis, physiology, and behavior. It is easy to study gene function by generating transgenic zebrafish, by knocking down gene function with morpholino antisense oligonucleotides, or by altering gene function by genome editing. The genome has been sequenced and about 50% of the protein coding genes have been mutated by targeted gene knockout technology. Large-scale projects are underway or planned that will produce functional data about almost all the genes and sequence-based functional elements in the genome. Multiple mutations and gene knockdowns can be combined in the same individual to study gene modifiers and other genetic interactions. The functions of most of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene functions in other vertebrates, including humans. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic, developmental, and physiological information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology, and f) to help serve the broad needs of the biomedical research community. This project will continue and expand curation of zebrafish research data, develop expanded support for zebrafish models of human disease, expand and integrate links to other databases, and maintain and update the zebrafish reference genome. This work will provide a powerful means for researchers to associate gene sequence and function, thus facilitating studies of human gene function and disease as well as cross-species analyses of genome organization and evolution.