Endolysosomal two-pore channel's pivotal role in endocytic pathways and membrane protein trafficking

内溶酶体双孔通道在内吞途径和膜蛋白运输中的关键作用

• 批准号: 2885841
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885841
• 关键词: Endolysosomal; two; pore; channel; pivotal

My research will advance current understandings of how key endocytic events, such as clathrin-mediated endocytosis, and membrane trafficking are regulated, applying this knowledge to diseases in which endolysosomal dysfunction is pivotal. Additionally, my PhD will question the rationale behind multi-isoform TPCs, especially TPC1, which is often the 'overlooked' isoform. I am enthusiastic to apply the various laboratory-based skills I am currently mastering during my research masters within the Galione group at the University of Oxford, including tissue culturing and transient transfection. In maintaining my high standards, and alert, organised and systematic nature which was recognised in graduating with a 1st Class Bachelor of Science with Honours, I endeavour to continue excelling academically in an area I am extremely passionate about. I am in a strong position, equipped with the experience and skills needed to conduct high quality research with purposeful results.

我的研究将推进目前的理解关键的内吞事件，如网格蛋白介导的内吞作用，和膜贩运的调节，应用这些知识的疾病，其中内溶酶体功能障碍是关键。此外，我的博士学位将质疑多亚型TPC背后的基本原理，特别是TPC 1，它通常是“被忽视的”亚型。我热衷于应用各种基于实验室的技能，我目前掌握在我的研究硕士在牛津大学Galione组，包括组织培养和瞬时转染。在保持我的高标准，警觉，有组织和系统的性质，这是在毕业时与科学荣誉学士学位的第一类认可，我努力继续在学术上我非常热衷于一个领域的卓越。我处于有利地位，具备进行高质量研究并获得有目的结果所需的经验和技能。