Genetic and biochemical mechanisms dysregulating CD4 T cell tolerance in organ-specific autoimmunity

器官特异性自身免疫中 CD4 T 细胞耐受失调的遗传和生化机制

• 批准号: nhmrc : 224265
• 负责人: Prof Christopher Goodnow
• 金额: $ 30.41万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-biochemical-mechanisms-specific-autoimmunity/96205
• 关键词: Genetic; biochemical; mechanisms; dysregulating; CD4

This project will analyse mechanisms that regulate CD4 T cells and normally prevent the immune system from attacking parts of our own body. Unknown errors in the control of T cells result in autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and thyroid disease, where T cells damage or destroy vital organs. In order to develop rational, specific methods for treating and preventing these diseases, it is necessary to identify and understand the genetic and biochemical mechanisms that normally control T cell cell responses to self components, and how inherited defects lead these mechanisms to break down. The project focuses on defining how CD4 T cell regulation breaks down in two well established examples of inherited susceptibility to autoimmune disease. The direct action of autoimmune susceptibility genes will be determined at the level of the specific T cells responsible for autoimmune attack and in terms of the biochemical pathways within T cells that are dysregulated. By identifying the mechanisms and biochemical pathways that are dysregulated in autoimmune disorders, the results of this project will reveal targets for understanding and diagnosing autoimmune diseases and for developing new drugs or or vaccines to prevent T cells damaging vital organs and cure these diseases.

该项目将分析调节CD4 T细胞的机制，并通常防止免疫系统攻击我们自己的身体部位。T细胞控制中的未知错误导致自身免疫性疾病，如1型糖尿病，多发性硬化症和甲状腺疾病，其中T细胞损伤或破坏重要器官。为了开发治疗和预防这些疾病的合理，具体的方法，有必要确定和理解通常控制T细胞对自身成分反应的遗传和生化机制，以及遗传缺陷如何导致这些机制被破坏。该项目的重点是确定CD4 T细胞调节如何在两个已建立的遗传性自身免疫性疾病易感性的例子中被破坏。自身免疫易感性基因的直接作用将在负责自身免疫攻击的特异性T细胞水平和失调的T细胞内的生化途径方面确定。通过确定自身免疫性疾病中失调的机制和生化途径，该项目的结果将揭示理解和诊断自身免疫性疾病以及开发新药或疫苗以防止T细胞损伤重要器官并治愈这些疾病的目标。