BACTERIA-ON-A-CHIP: Microfluidic chemostats to decipher the responsiveness of bacterial communities

BACTERIA-ON-A-CHIP：微流控恒化器破译细菌群落的反应性

• 批准号: 2886982
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2886982
• 关键词: BACTERIA; CHIP; Microfluidic; chemostats; decipher

This project will pursue the next frontier in soil microbiome research by combining microfluidics, microscopy and sequencing to investigate microbial activation. Our objective is to engineer 'BACTERIA-ON-A-CHIP' microfluidic technologies to decipher the responsiveness of bacterial communities at single-cell level. We aim to develop microfluidic chemostats to understand spore activation, assess the responsiveness of complex bacterial communities, isolate and identify species that exhibit very high reactivity and develop closed-loop microfluidic platforms to steer gene expression or cell behaviour towards desired goals to aid the identification of new bioinoculants, optimise plant growth and improve sustainability in agriculture.

该项目将通过结合微流体，显微镜和测序来研究微生物活化，从而探索土壤微生物组研究的下一个前沿领域。我们的目标是设计“BACHIA-ON-A-CHIP”微流体技术，以在单细胞水平上破译细菌群落的反应性。我们的目标是开发微流控恒化器，以了解孢子激活，评估复杂细菌群落的反应性，分离和识别表现出非常高反应性的物种，并开发闭环微流控平台，以引导基因表达或细胞行为实现预期目标，以帮助识别新的生物接种剂，优化植物生长并提高农业的可持续性。