Mechanisms of Alcohol-Induced Tissue Injury
酒精引起的组织损伤的机制
基本信息
- 批准号:7214186
- 负责人:
- 金额:$ 41.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-04-20 至 2010-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAlcohol withdrawal syndromeAlcoholic IntoxicationAlcoholsAlteplaseAmygdaloid structureAttenuatedCellsCessation of lifeChronicDisruptionEndopeptidasesEnzyme PrecursorsEquilibriumEthanolExcitatory NeurotoxinsExtracellular MatrixGelatinase BGeneticHippocampus (Brain)Injection of therapeutic agentInjuryInterventionLaboratoriesLamininMatrix MetalloproteinasesMediatingMusN-MethylaspartateNerve DegenerationNeuraxisNeuronsPathologyPathway interactionsPeptide HydrolasesPlasminPlasminogenPlasminogen Activator Inhibitor 1PlayPrimary Cell CulturesProcessProtease InhibitorRegulationResearch PersonnelRoleSeizuresSerine Proteinase InhibitorsSerpinsSystemTestingTissuesWild Type MouseWithdrawalcell typeexcitotoxicityinhibitor/antagonistneuron lossneuroprotectionneuroserpinneurotoxicityreceptorresearch studysmall molecule
项目摘要
DESCRIPTION (provided by applicant): It has been shown in various laboratories that the tissue plasminogen activator (tPA)/plasmin system is critical for excitotoxin-mediated seizures and neurodegeneration in the hippocampus. Upon excitotoxic challenge, tPA activates plasminogen to produce excess plasmin, which then degrades a critical component of the extracellular matrix (ECM), laminin. The loss of the neuron-matrix connection facilitates neuronal death as it does with other cell types.
We have found that tPA activity during ethanol treatment and EW is up-regulated in the mouse hippocampus and the amygdala, and that tPA-/- mice are protected from EW-induced seizures and neurodegeneration, as they are from these pathologies induced by excitotoxin injection. Therefore, the mechanism(s) of excitotoxinand EW-induced seizures and neurodegeneration have at least one molecule in common, tPA.
To understand better the mechanism of EW-induced seizures and neurodegeneration, we propose to systematically explore the role of tPA in these processes
描述(由申请人提供):多个实验室表明,组织纤溶酶原激活剂(tPA)/纤溶酶系统对兴奋毒素介导的癫痫发作和海马神经退行性变至关重要。在兴奋性毒性刺激下,tPA激活纤溶酶原产生过量的纤溶酶,然后降解细胞外基质(ECM)的关键成分层粘连蛋白。神经元-基质连接的丧失促进了神经元的死亡,就像其他类型的细胞一样。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SIDNEY STRICKLAND其他文献
SIDNEY STRICKLAND的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SIDNEY STRICKLAND', 18)}}的其他基金
Role of the tPA/plasmin System in Alzheimers Disease
tPA/纤溶酶系统在阿尔茨海默病中的作用
- 批准号:
7112914 - 财政年份:2004
- 资助金额:
$ 41.59万 - 项目类别:
Role of the tPA/plasmin System in Alzheimers Disease
tPA/纤溶酶系统在阿尔茨海默病中的作用
- 批准号:
7480226 - 财政年份:2004
- 资助金额:
$ 41.59万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 41.59万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 41.59万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 41.59万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 41.59万 - 项目类别:
Studentship