Initial presentations of multiple sclerosis: understanding pathways to diagnosis Filled

多发性硬化症的初步表现：了解诊断途径 Filled

• 批准号: 2887342
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2887342
• 关键词: Initial; presentations; multiple; sclerosis; understanding

This PhD aims to better understand how people subsequently diagnosed with multiple sclerosis (MS)experience their initial symptoms and present to primary care. The student will firstly examine this from the patient perspective, before using large healthcare datasets to examine and understand the similarities and differences between patient experiences and documented diagnoses.People with MS experience a variety of symptoms before they are diagnosed, and large studies from the UK and overseas have shown that they have more appointments with GPs and other healthcare providers for 5 years before they are formally diagnosed. However, it remains unknown how people subsequently diagnosed with MS make decisions about how and when to seek medical care at the earliest stage of their disease journey.The student will seek to understand when people with MS perceive their symptoms to have started, and how they interact with healthcare professionals at this time. They will examine the potential barriers that different people with MS face in terms of onward referral from primary care using focused interviews with people newly diagnosed with MS in East London. This will allow the student to understand the impact of social determinants of health including race, ethnicity, gender and socioeconomic deprivation on pathways to MS diagnosis within a uniquely diverse and deprived population.The student will then take advantage of linked healthcare datasets available in East London to examine how these reported symptoms are recorded in primary care records. They will perform a detailed study of the healthcare records of people who have taken part in the first part of the study, facilitating an understanding of how symptoms might be recorded across different groups of people who subsequently receive an MS diagnosis. They will then use a large, diverse primary care dataset of >1,000,000 people in East London (>1000 with MS) to understand patterns in the way that symptoms are recorded, and how these reflectand differ from the experience of people subsequently diagnosed with MS.Collaboration with the MS Society is embedded across the PhD, including public involvement training. During their final year, the student will complete an internship within the Research & External Affairs directorate at the MS Society in order to ensure policy impact from their findings. They will collaborate with the MS Society Research Communications team to disseminate findings to people affected by MS via a number of channels, to improve public knowledge and awareness.

该博士旨在更好地了解随后被诊断为多发性硬化症 (MS) 的人们如何经历其最初症状并就医。学生将首先从患者的角度进行检查，然后使用大型医疗数据集来检查和理解患者经历和记录诊断之间的异同。多发性硬化症患者在被诊断之前会经历各种症状，来自英国和海外的大型研究表明，他们在正式诊断之前的 5 年内会更多地与全科医生和其他医疗保健提供者进行预约。然而，目前尚不清楚随后被诊断为多发性硬化症的人如何决定在疾病旅程的最早阶段如何以及何时寻求医疗护理。学生将努力了解多发性硬化症患者何时意识到自己的症状已经开始，以及他们此时如何与医疗保健专业人员互动。他们将通过对东伦敦新诊断出的多发性硬化症患者进行集中访谈，研究不同的多发性硬化症患者在从初级保健转诊方面面临的潜在障碍。这将使学生能够了解健康的社会决定因素（包括种族、民族、性别和社会经济剥夺）对独特多样化和贫困人群中多发性硬化症诊断途径的影响。然后，学生将利用东伦敦可用的链接医疗数据集来检查这些报告的症状是如何记录在初级保健记录中的。他们将对参与第一部分研究的人员的医疗记录进行详细研究，以帮助了解随后接受多发性硬化症诊断的不同人群的症状是如何记录的。然后，他们将使用东伦敦超过 1,000,000 人（超过 1000 名多发性硬化症患者）的大型、多样化的初级保健数据集来了解症状记录方式的模式，以及这些症状如何反映并与随后诊断为多发性硬化症的人的经历有何不同。与多发性硬化症协会的合作贯穿整个博士学位，包括公众参与培训。在最后一年，学生将在多发性硬化症协会研究与外部事务理事会完成实习，以确保他们的研究结果产生政策影响。他们将与多发性硬化症协会研究传播团队合作，通过多种渠道向受多发性硬化症影响的人们传播研究结果，以提高公众的知识和意识。