Initial presentations of multiple sclerosis: understanding pathways to diagnosis Filled

多发性硬化症的初步表现:了解诊断途径 Filled

基本信息

  • 批准号:
    2887342
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    未结题

项目摘要

This PhD aims to better understand how people subsequently diagnosed with multiple sclerosis (MS)experience their initial symptoms and present to primary care. The student will firstly examine this from the patient perspective, before using large healthcare datasets to examine and understand the similarities and differences between patient experiences and documented diagnoses.People with MS experience a variety of symptoms before they are diagnosed, and large studies from the UK and overseas have shown that they have more appointments with GPs and other healthcare providers for 5 years before they are formally diagnosed. However, it remains unknown how people subsequently diagnosed with MS make decisions about how and when to seek medical care at the earliest stage of their disease journey.The student will seek to understand when people with MS perceive their symptoms to have started, and how they interact with healthcare professionals at this time. They will examine the potential barriers that different people with MS face in terms of onward referral from primary care using focused interviews with people newly diagnosed with MS in East London. This will allow the student to understand the impact of social determinants of health including race, ethnicity, gender and socioeconomic deprivation on pathways to MS diagnosis within a uniquely diverse and deprived population.The student will then take advantage of linked healthcare datasets available in East London to examine how these reported symptoms are recorded in primary care records. They will perform a detailed study of the healthcare records of people who have taken part in the first part of the study, facilitating an understanding of how symptoms might be recorded across different groups of people who subsequently receive an MS diagnosis. They will then use a large, diverse primary care dataset of >1,000,000 people in East London (>1000 with MS) to understand patterns in the way that symptoms are recorded, and how these reflectand differ from the experience of people subsequently diagnosed with MS.Collaboration with the MS Society is embedded across the PhD, including public involvement training. During their final year, the student will complete an internship within the Research & External Affairs directorate at the MS Society in order to ensure policy impact from their findings. They will collaborate with the MS Society Research Communications team to disseminate findings to people affected by MS via a number of channels, to improve public knowledge and awareness.
该博士旨在更好地了解随后被诊断患有多发性硬化症(MS)的人如何经历他们的初始症状并呈现给初级保健。学生将首先从患者的角度进行研究,然后使用大型医疗数据集来检查和理解患者经历和记录诊断之间的相似性和差异。MS患者在被诊断之前会经历各种症状,来自英国和海外的大型研究表明,他们在正式加入前5年与全科医生和其他医疗保健提供者的预约更多。诊断。然而,目前尚不清楚后来被诊断为MS的人如何在疾病的最早阶段决定如何以及何时寻求医疗护理。学生将试图了解MS患者何时认为他们的症状已经开始,以及他们如何与医疗保健专业人员互动。他们将通过对东伦敦新诊断为多发性硬化症的人进行重点访谈,研究不同的多发性硬化症患者在从初级保健转介方面面临的潜在障碍。这将使学生了解健康的社会决定因素的影响,包括种族,民族,性别和社会经济剥夺的路径MS诊断在一个独特的多样化和贫困人口。学生将利用链接的医疗保健数据集在东伦敦,检查这些报告的症状是如何记录在初级保健记录。他们将对参加研究第一部分的人的医疗记录进行详细研究,以便于了解随后接受MS诊断的不同人群如何记录症状。然后,他们将使用东伦敦> 1,000,000人的大型,多样化的初级保健数据集(>1000 MS)来了解症状记录方式的模式,以及这些如何反映和区别于随后诊断为MS的人的经验。在他们的最后一年,学生将在MS社会的研究和对外事务董事会完成实习,以确保他们的研究结果的政策影响。他们将与MS社会研究传播团队合作,通过多种渠道向受MS影响的人传播研究结果,以提高公众的知识和意识。

项目成果

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其他文献

吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
  • DOI:
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    0
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LiDAR Implementations for Autonomous Vehicle Applications
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
生命分子工学・海洋生命工学研究室
生物分子工程/海洋生物技术实验室
  • DOI:
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    0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
  • DOI:
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    0
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
  • DOI:
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    0
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{{ truncateString('', 18)}}的其他基金

An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
  • 批准号:
    2901954
  • 财政年份:
    2028
  • 资助金额:
    --
  • 项目类别:
    Studentship
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  • 批准号:
    2896097
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
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    --
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    2908918
  • 财政年份:
    2027
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    --
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质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
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    2908693
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    2027
  • 资助金额:
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Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
  • 批准号:
    2908917
  • 财政年份:
    2027
  • 资助金额:
    --
  • 项目类别:
    Studentship
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评估用于航空航天应用的新型抗疲劳钛合金
  • 批准号:
    2879438
  • 财政年份:
    2027
  • 资助金额:
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  • 项目类别:
    Studentship
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    2890513
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    2027
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    2876993
  • 财政年份:
    2027
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    --
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