Initial presentations of multiple sclerosis: understanding pathways to diagnosis Filled

多发性硬化症的初步表现：了解诊断途径 Filled

• 批准号: 2887342
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2887342
• 关键词: Initial; presentations; multiple; sclerosis; understanding

This PhD aims to better understand how people subsequently diagnosed with multiple sclerosis (MS)experience their initial symptoms and present to primary care. The student will firstly examine this from the patient perspective, before using large healthcare datasets to examine and understand the similarities and differences between patient experiences and documented diagnoses.People with MS experience a variety of symptoms before they are diagnosed, and large studies from the UK and overseas have shown that they have more appointments with GPs and other healthcare providers for 5 years before they are formally diagnosed. However, it remains unknown how people subsequently diagnosed with MS make decisions about how and when to seek medical care at the earliest stage of their disease journey.The student will seek to understand when people with MS perceive their symptoms to have started, and how they interact with healthcare professionals at this time. They will examine the potential barriers that different people with MS face in terms of onward referral from primary care using focused interviews with people newly diagnosed with MS in East London. This will allow the student to understand the impact of social determinants of health including race, ethnicity, gender and socioeconomic deprivation on pathways to MS diagnosis within a uniquely diverse and deprived population.The student will then take advantage of linked healthcare datasets available in East London to examine how these reported symptoms are recorded in primary care records. They will perform a detailed study of the healthcare records of people who have taken part in the first part of the study, facilitating an understanding of how symptoms might be recorded across different groups of people who subsequently receive an MS diagnosis. They will then use a large, diverse primary care dataset of >1,000,000 people in East London (>1000 with MS) to understand patterns in the way that symptoms are recorded, and how these reflectand differ from the experience of people subsequently diagnosed with MS.Collaboration with the MS Society is embedded across the PhD, including public involvement training. During their final year, the student will complete an internship within the Research & External Affairs directorate at the MS Society in order to ensure policy impact from their findings. They will collaborate with the MS Society Research Communications team to disseminate findings to people affected by MS via a number of channels, to improve public knowledge and awareness.

该博士旨在更好地了解后来诊断出多发性硬化症（MS）的人们如何经历其最初症状并提供初级保健。在使用大型医疗保健数据集来检查和理解患者经历和记录的诊断之间的相似性和差异之前，该学生将首先从患者的角度研究这一点。MS经历了多种症状，在被诊断出症状之前，来自英国和海外的大量症状表明，他们与GPS和其他医疗保健提供者有更多的预约，并在5年前被诊断出来。但是，尚不清楚如何在其疾病之旅的最早阶段就如何以及何时诊断为MS的人们如何做出决定。学生将寻求了解何时患有MS的人何时感知自己的症状开始，以及他们目前如何与医疗保健专业人员互动。他们将利用与新诊断为东伦敦MS的人进行的重点访谈，研究MS面对不同人面对不同人的潜在障碍。这将使学生能够理解健康的社会决定因素，包括种族，种族，性别和社会经济剥夺对在独特多样化和被剥夺人群中MS诊断途径的途径。然后，学生将利用伦敦东部可用的链接的医疗保健数据集，以研究如何在主护理记录中记录这些报告的症状。他们将对参与研究第一部分的人们的医疗记录进行详细研究，从而促进了解如何在随后接受MS诊断的不同人群中记录症状。然后，他们将使用东伦敦（East London）> 1,000,000人的大型，多样化的初级保健数据集（> 1000个带有MS），以记录症状的方式来理解模式，以及这些反思与随后诊断出与MS社会进行诊断为MS社会的经验的经验不同，包括公众参与培训，包括公众参与培训。在最后一年，学生将完成MS协会研究与外部事务局的实习，以确保其发现的政策影响。他们将与MS Society Research Communations团队合作，通过许多渠道向受MS影响的人们传播发现，以提高公众知识和意识。