Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis

动脉粥样硬化颈动脉内膜内侧厚度 (IMT) 的流行病学

• 批准号: 7230446
• 负责人: JOSEPH F POLAK
• 金额: $ 22.55万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7230446
• 关键词: Age Distribution; Ancillary Study; Arts; Atherosclerosis; Biological Process; Calcium; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Atherosclerotic Disease; Cause of Death; Clinical; Coronary; Coronary Arteriosclerosis; Coronary artery; Data; Databases; Development; Disease; Disease Progression; Early Diagnosis; End Point; Epidemiology; Event; Exposure to; Future; Grant; Guide prevention; Head; High Prevalence; Individual; Intervention; Invasive; Measurement; Measures; Medial; Methods; Modeling; Myocardial Infarction; Participant; Personal Satisfaction; Phase; Prevention intervention; Protocols documentation; Publishing; Recruitment Activity; Research Personnel; Resolution; Risk; Risk Factors; Schedule; Score; Stroke; Technology; Testing; Thick; Time; Ultrasonography; United States; Work; X-Ray Computed Tomography; burden of illness; cardiovascular disorder risk; cardiovascular risk factor; cohort; cost; design; follow-up; millimeter; programs; time interval

DESCRIPTION (provided by applicant): This application seeks to determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis. Changes in sub-clinical atherosclerotic disease are measured noninvasively using high resolution B-mode ultrasound and presented as changes in wall thickness (in millimeters) of the carotid artery (carotid IMT). Carotid IMT is well recognized as a measure of atherosclerotic burden. Progression of disease is hypothesized to precede the development of clinical events. The current application is also designed to be able to compare progression of carotid IMT with changes in coronary calcium score, a measure of coronary artery disease. Development of clinical atherosclerosis is evaluated by onset of clinical events (myocardial infarction, stroke, angina.) in an established cohort with a broad age-distribution and a multi-ethnic composition (MESA: Multi-Ethnic Study of Atherosclerosis). As compared to previous published works on the topic, this application offers the opportunity of measuring atherosclerosis across a broad age distribution and in a multi-ethnic cohort using state-of-the-art technologies.

描述（由申请人提供）：本申请旨在确定与亚临床动脉粥样硬化进展相关的因素，并评估亚临床动脉粥样硬化进展与临床表现动脉粥样硬化发展之间的关系。亚临床动脉粥样硬化疾病的变化是使用高分辨率b超无创测量的，并表现为颈动脉壁厚（以毫米为单位）的变化（颈动脉IMT）。颈动脉IMT是公认的衡量动脉粥样硬化负担的指标。疾病的进展被假设先于临床事件的发展。目前的应用程序还设计用于比较颈动脉IMT的进展与冠状动脉钙评分的变化，冠状动脉疾病的测量。临床动脉粥样硬化的发展是通过临床事件（心肌梗死、中风、心绞痛）的发作来评估的，该队列具有广泛的年龄分布和多民族组成（MESA：多民族动脉粥样硬化研究）。与先前发表的关于该主题的作品相比，该应用程序提供了使用最先进技术在广泛的年龄分布和多种族队列中测量动脉粥样硬化的机会。

项目成果

Carotid Intima-Media Thickness Score, Positive Coronary Artery Calcium Score, and Incident Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis.

• DOI: 10.1161/jaha.116.004612
• 发表时间: 2017-01-21
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Polak JF;Szklo M;O'Leary DH
• 通讯作者: O'Leary DH

Variations in common carotid artery intima-media thickness during the cardiac cycle: implications for cardiovascular risk assessment.

• DOI: 10.1016/j.echo.2012.05.007
• 发表时间: 2012-09
• 期刊: JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
• 影响因子: 6.5
• 作者: Polak, Joseph F.;Meisner, Allison;Pencina, Michael J.;Wolf, Philip A.;D'Agostino, Ralph B.
• 通讯作者: D'Agostino, Ralph B.

Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT.

• DOI: 10.7863/jum.2010.29.12.1759
• 发表时间: 2010-12
• 期刊: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
• 作者: Polak JF;Pencina MJ;Meisner A;Pencina KM;Brown LS;Wolf PA;D'Agostino RB Sr
• 通讯作者: D'Agostino RB Sr

Associations of edge-detected and manual-traced common carotid artery intima-media thickness with incident peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis.

边缘检测和手动追踪颈总动脉内膜中层厚度与外周动脉疾病的关联：动脉粥样硬化的多种族研究。

• DOI: 10.1177/1358863x19835925
• 发表时间: 2019
• 期刊: Vascular medicine (London, England)
• 作者: Polak,JosephF;Herrington,David;O'Leary,DanielH
• 通讯作者: O'Leary,DanielH

Carotid-wall intima-media thickness and cardiovascular events.

• DOI: 10.1056/nejmoa1012592
• 发表时间: 2011-07-21
• 期刊: The New England journal of medicine
• 作者: Polak JF;Pencina MJ;Pencina KM;O'Donnell CJ;Wolf PA;D'Agostino RB Sr
• 通讯作者: D'Agostino RB Sr