Epidemiology of Cartoid IMT Progression in MESA

描述(申请人提供)：本申请旨在确定与亚临床动脉粥样硬化进展相关的因素，并评估亚临床动脉粥样硬化进展与临床显性动脉粥样硬化发展之间的关系。亚临床动脉粥样硬化性疾病的变化是使用高分辨率B型超声无创测量的，并表现为颈动脉(颈动脉IMT)壁厚(毫米)的变化。颈动脉IMT被公认为是动脉粥样硬化负担的一种衡量标准。疾病的进展被认为先于临床事件的发展。目前的应用还被设计为能够比较颈动脉IMT的进展与冠状动脉钙化评分的变化，冠状动脉钙化评分是衡量冠状动脉疾病的指标。临床动脉粥样硬化的发展通过临床事件(心肌梗塞、中风、心绞痛)的发生来评估。在具有广泛年龄分布和多种族构成的既定队列中(MESA：动脉粥样硬化的多种族研究)。与以前发表的关于这一主题的工作相比，这项应用提供了使用最先进的技术在广泛的年龄分布和多种族队列中测量动脉粥样硬化的机会。

DESCRIPTION (provided by applicant): This application seeks to determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis. Changes in sub-clinical atherosclerotic disease are measured noninvasively using high resolution B-mode ultrasound and presented as changes in wall thickness (in millimeters) of the carotid artery (carotid IMT). Carotid IMT is well recognized as a measure of atherosclerotic burden. Progression of disease is hypothesized to precede the development of clinical events. The current application is also designed to be able to compare progression of carotid IMT with changes in coronary calcium score, a measure of coronary artery disease. Development of clinical atherosclerosis is evaluated by onset of clinical events (myocardial infarction, stroke, angina.) in an established cohort with a broad age-distribution and a multi-ethnic composition (MESA: Multi-Ethnic Study of Atherosclerosis). As compared to previous published works on the topic, this application offers the opportunity of measuring atherosclerosis across a broad age distribution and in a multi-ethnic cohort using state-of-the-art technologies.