Progression of sub-clinical Atherosclerosis

亚临床动脉粥样硬化的进展

• 批准号: 7114506
• 负责人: JOSEPH F POLAK
• 金额: $ 54.59万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114506
• 关键词: acute phase protein; angiocardioultrasonography; atherosclerosis; bioimaging /biomedical imaging; biomarker; cardiovascular disorder risk; carotid artery; clinical research; homocysteine; human subject; longitudinal human study; pathologic process

DESCRIPTION (provided by applicant): Strong associations exist between cardiovascular events and increased carotid artery wall intima-media thickness (IMT) as measured non-invasively by carotid ultrasound. Carotid IMT is accepted as a surrogate marker of sub-clinical cardiovascular disease. We propose to determine the rate of progression of sub-clinical cardiovascular disease (change in IMT) over a period of 8 to 10 years. Imaging and IMT measurements of approximately 2800 to 3000 members of this cohort having had baseline IMT measurements at their 1995-98 clinic visit will be repeated in 200:5-2007. The principal aims of the project are to study the primary hypotheses that: 1. Interim exposure to traditional cardiovascular risk factors measured over 50 years is positively associated with the progression rate of carotid IMT. 2. Baseline carotid IMT and cumulative exposure to cardiovascular risk factors 20 years before the baseline visit are a better predictor of progression of sub-clinical disease after 8 to 10 years than the interim exposure to risk factors. 3. Novel risk factors such as C-reactive protein and homocysteine affect progression of carotid atherosclerosis more than traditional risk factors. This application will add a phenotypic marker of site-specific change in sub-clinical cardiovascular disease to the Framingham Study database. This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers.

描述（由申请人提供）：在心血管事件和颈动脉壁内膜厚度（IMT）之间存在强烈的关联，如颈动脉超声而非无创测量。颈动脉IMT被接受为亚临床心血管疾病的替代标记。我们建议在8至10年期间确定下临床心血管疾病（IMT的变化）的进展率。在1995 - 98年的诊所访问中，该队列中大约2800至3000名成员的成像和IMT测量将在200：5-2007重复进行。该项目的主要目的是研究：1。在50年内测得的传统心血管危险因素的临时暴露与颈动脉IMT的进展率呈正相关。 2。基线IMT和累积暴露于基线访问前20年的心血管危险因素是更好地预测8至10年后亚临床疾病进展的因素，而不是临时暴露于风险因素。 3。与传统危险因素相比，诸如C反应蛋白和同型半胱氨酸等新型危险因素会影响颈动脉粥样硬化的进展。该应用将为弗雷明汉研究数据库增加一个位点特异性变化的表型标记。这补充了关于亚临床心血管疾病进展的持续研究及其与过早心血管事件和基因组标志家族史的关联。