Development of a Multi-sample Solids NMR Probe

项目摘要 此应用程序的目标是实现更高效和更具成本效益的使用 用于医疗保健研究的固态核磁共振系统。固态核磁共振波谱是 分析药物和生物化合物的重要工具，如 蛋白质，但由于收集数据所需的时间较长，通常不使用。这个 具体目的是设计并商业化多样品固体(MSS)探头 同时分析最多六个样本。在第一阶段，现有的MSS设计 概念是由革命核磁共振和堪萨斯大学开发的，用于操作 在200-400 MHz范围内，利用Revise在探测方面的经验和能力 设计。在第二阶段，这一设计将得到改进，以便探测器能够 执行当前大多数固体核磁共振实验，包括三个 共振能力。此外，MSS的设计将进行修改，以便在高 适用于各种频率(高达900 MHz)的磁铁以及中小型孔径磁铁。

Project Summary The objective of this application is to enable more efficient and cost-effective utilization of solid-state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific aim is to design and commercialize a multi-sample solids (MSS) probe capable of analyzing up to six samples simultaneously. In Phase I, an existing MSS design concept was developed by Revolution NMR and the University of Kansas for operation in the 200 - 400 MHz range, utilizing Revolution's experience and capabilities in probe design. In Phase II, this design will be enhanced so that the probe would be capable of performing most of the current suite of solids NMR experiments, including triple resonance capabilities. In addition, the MSS design will be modified for use at high frequencies (up to 900 MHz) as well as small and medium bore magnet sizes.