Development of a Multi-sample Solids NMR Probe

多样品固体核磁共振探针的开发

• 批准号: 7503531
• 负责人: John Patrick Heinrich
• 金额: $ 0.93万
• 依托单位: REVOLUTION NMR, LLC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7503531
• 关键词: Biological; Characteristics; Data; Data Analyses; Development; Equipment; Facility Construction Funding Category; Frequencies; Goals; Health Services Research; Healthcare Systems; Kansas; Length; Marketing; Mechanics; NMR Spectroscopy; Nuclear Magnetic Resonance; Nucleic Acids; Numbers; Operative Surgical Procedures; Pharmaceutical Chemistry; Pharmacologic Substance; Phase; Positioning Attribute; Procedures; Proteins; Range; Research; Role; Sampling; Small Business Technology Transfer Research; Solid; Staging; System; Technology; Testing; Time; Universities; Validation; base; biological research; concept; cost; data acquisition; design; engineering design; experience; programs; prototype; research study; size; solid state; tool

Project Summary The objective of this application is to enable more efficient and cost-effective utilization of solid-state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific aim is to design and commercialize a multi-sample solids (MSS) probe capable of analyzing up to six samples simultaneously. In Phase I, an existing MSS design concept was developed by Revolution NMR and the University of Kansas for operation in the 200 - 400 MHz range, utilizing Revolution's experience and capabilities in probe design. In Phase II, this design will be enhanced so that the probe would be capable of performing most of the current suite of solids NMR experiments, including triple resonance capabilities. In addition, the MSS design will be modified for use at high frequencies (up to 900 MHz) as well as small and medium bore magnet sizes.

项目摘要 此应用程序的目标是实现更有效和更具成本效益的利用 用于医疗研究的固态核磁共振系统。固态核磁共振光谱是 是分析药物和生物化合物的重要工具， 蛋白质，但由于收集数据所需的时间长度，通常不使用。的 具体目标是设计和商业化多样品固体（MSS）探针，其能够 同时分析六个样本。在第一阶段，现有的MSS设计 这一概念是由革命核磁共振和堪萨斯大学开发的， 在200 - 400兆赫范围内，利用革命的经验和能力，在探测 设计在第二阶段，这种设计将得到加强，使探头能够 执行大多数目前的固体核磁共振实验套件，包括三重 共振能力。此外，MSS的设计将被修改，以用于高 频率（高达900 MHz）以及小和中等孔径磁体尺寸。