Development of a Multi-sample Solids NMR Probe

描述（由申请人提供）：本申请的目的是使固体核磁共振系统在医疗保健研究中更有效和更具成本效益。固态核磁共振波谱是分析药物和生物化合物（如蛋白质）的重要工具，但由于收集数据所需的时间长，通常不使用。具体目标是设计和商业化的多样品固体（MSS）探针能够同时分析多达6个样品。在第一阶段，基于Revolution在探针设计方面的经验和能力，Revolution NMR将开发堪萨斯大学现有的MSS设计概念，用于200-500 MHz范围内的工作。该MSS设计将在第二阶段进行修改，以用于高频（高达800 MHz）。固态核磁共振（NMR）是分析新药和生物分子的一种非常强大的工具，但由于一些实验可能需要几天或几周的时间，它的使用往往受到限制。该项目将提供一种新的工具，可以同时分析多达6个样本。制药公司、政府实验室和大学将能够在新疗法的开发中更经济有效地使用他们的核磁共振系统。

DESCRIPTION (provided by applicant): The objective of this application is to enable more efficient and cost-effective utilization of solid state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of Pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific aim is to design and commercialize a multi-sample solids (MSS) probe capable of analyzing up to 6 samples simultaneously. In Phase I, an existing MSS design concept from the University of Kansas will be developed by Revolution NMR for operation in the 200-500 MHz range, based on Revolution's experience and capabilities in probe design. This MSS design will be modified for use at high frequencies (up to 800 MHz) in Phase II. Solid state nuclear magnetic resonance (NMR) is a very powerful tool for the analysis of new drugs and biomolecules, but its use is often limited by the fact that some experiments can require days or weeks. This project will provide a new tool which will allow up to 6 samples to be analyzed simultaneously. Pharmaceutical companies, government laboratories, and universities will be able to make more cost effective use of their NMR systems in the development of new therapies.