Development of a Multi-sample Solids NMR Probe

多样品固体核磁共振探针的开发

• 批准号: 7328159
• 负责人: John Patrick Heinrich
• 金额: $ 39.3万
• 依托单位: REVOLUTION NMR, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-22 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7328159
• 关键词: Biological; Characteristics; Data; Data Analyses; Development; Equipment; Facility Construction Funding Category; Frequencies; Goals; Government; Health Services Research; Healthcare Systems; Kansas; Laboratories; Length; Marketing; Mechanics; NMR Spectroscopy; Nuclear Magnetic Resonance; Nucleic Acids; Numbers; Operative Surgical Procedures; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Positioning Attribute; Procedures; Proteins; Range; Research; Role; Sampling; Small Business Technology Transfer Research; Solid; Staging; System; Technology; Testing; Time; Universities; Validation; Week; base; biological research; concept; cost; data acquisition; day; design; engineering design; experience; programs; prototype; research study; size; solid state; tool

DESCRIPTION (provided by applicant): The objective of this application is to enable more efficient and cost-effective utilization of solid-state NMR systems for health care research. Solid-state NMR spectroscopy is an important tool for the analysis of pharmaceuticals and biological compounds such as proteins, but is often not used due to the length of time required to collect data. The specific aim is to design and commercialize a multi-sample solids (MSS) probe capable of analyzing up to six samples simultaneously. In Phase I, an existing MSS design concept was developed by Revolution NMR and the University of Kansas for operation in the 200 - 400 MHz range, utilizing Revolution's experience and capabilities in probe design. In Phase II, this design will be enhanced so that the probe would be capable of performing most of the current suite of solids NMR experiments, including triple resonance capabilities. In addition, the MSS design will be modified for use at high frequencies (up to 900 MHz) as well as small and medium bore magnet sizes. Solid state nuclear magnetic resonance (NMR) is a very powerful tool for the analysis of new drugs and biomolecules, but its use is often limited by the fact that some experiments can require days or weeks. This project will provide a new tool which will allow up to six samples to be analyzed simultaneously. Pharmaceutical companies, government laboratories, and universities will be able to make more cost-effective use of their NMR systems in the development of new therapies

描述(由申请人提供)：本申请的目标是使固态核磁共振系统更有效和更具成本效益地用于医疗保健研究。固态核磁共振光谱学是分析药物和蛋白质等生物化合物的重要工具，但由于收集数据所需的时间较长，通常不使用。其具体目标是设计一种多样品固体(MSS)探测器并将其商业化，该探测器能够同时分析多达六个样品。在第一阶段，现有的MSS设计概念是由Revise核磁共振公司和堪萨斯大学开发的，用于在200-400 MHz范围内运行，利用Revise公司在探测器设计方面的经验和能力。在第二阶段，这一设计将得到改进，以便探测器能够执行目前大多数固体核磁共振实验，包括三重共振能力。此外，MSS的设计将进行修改，以用于高频(高达900 MHz)以及中小口径磁铁。固态核磁共振是分析新药和生物分子的一种非常强大的工具，但它的使用往往受到一些实验可能需要几天或几周的事实的限制。该项目将提供一种新的工具，允许同时分析多达六个样品。制药公司、政府实验室和大学将能够在开发新疗法时更具成本效益地使用他们的核磁共振系统。