Chiral Ionic Liquid Solvents for Asymmetric Synthesis

描述（由申请人提供）：这个小型企业创新研究第一阶段项目将研究新发现的离子液体（IL），这些离子液体是基于不对称有机阴离子，用于环保，无voc的“绿色”溶剂，包括四种新的室温离子液体（RTIL）。这些新溶剂已被证明可用于有机合成，特别是用于氧化。溶剂可以通过减少有害排放和监管成本，为不对称药物和中间体的合成提供更环保的途径。溶剂的外消旋形式已经被分离出来，预计将用于不对称氧化反应。通过使用离子液体溶剂的对映体纯版本，在不对称合成中可以产生额外的优势。液体范围可达-50°C至250°C，预计溶剂可在广泛的反应条件下使用。nGimat建议研究这种新型离子液体的性质，并开发更环保的不对称有机氧化方法。这项工作将为我们与商业化合作伙伴（一家财富500强的有机溶剂和高性能化学品制造商）合作应用这些材料的商业化努力提供科学基础。到目前为止，我们已经发现了四种室温离子液体（RTILs），在第一阶段，我们将对该系列中可能也是离子液体的其他成员进行搜索。最近对环境友好型产品的趋势已导致在产品配方和工业过程中使用绿色溶剂的增加。管理有害空气污染物（HAP）或挥发性有机化合物（VOC）溶剂使用的法规正在迫使公司寻找目前使用的溶剂的替代品。挥发性有机溶剂是挥发性有机化合物排放和有害空气污染的来源，与臭氧消耗和全球变暖有关，因此，有机会引入旨在消除工业过程中挥发性有机化合物排放的产品。nGimat的目标是在3-4年内推出满足这些需求的新型离子液体溶剂。nGimat将向制药、中间体、高性能化学品、有机溶剂或相关产品的生产企业授权二期开发的材料。

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will investigate newly discovered ionic liquids (IL's) that are based on asymmetric organic anions for use as environmentally friendly, VOC-free "green" solvents including four new room-temperature ionic liquids (RTIL's). These new solvents have been demonstrated for use in organic synthesis, and for oxidations in particular. The solvents may provide more environmentally benign pathways for synthesis of asymmetric drugs and intermediates by reducing harmful emissions and regulatory costs. The racemic forms of the solvents have already been isolated and are anticipated to have use for asymmetric oxidation reactions. Additional advantage in asymmetric synthesis may arise via the use of enantiomerically pure versions of the ionic liquid solvents. With liquid ranges as great as -50 ¿C to 250 ¿C, the solvents are anticipated to have use under a wide range of reaction conditions. nGimat proposes to investigate the properties of the new ionic liquids and develop more environmentally benign versions of asymmetric organic oxidations. This work will provide a scientific underpinning to the commercialization effort for these materials for applications in cooperation with our commercialization partner, a Fortune 500 manufacturer of organic solvents and performance chemicals. To date, we have discovered four room temperature ionic liquids (RTILs), and in Phase I, we will execute a search for additional members of the series that may also be ionic liquids. The recent trend towards environmentally friendly products has caused an increase in the use of green solvents in product formulations and industrial processes. Regulations governing the use of solvents classified as Hazardous Air Pollutants (HAP) or as Volatile Organic Compounds (VOC) are forcing companies to look for alternatives to solvents presently in use. Volatile organic solvents are a source of VOC emissions and hazardous air pollution and are implicated in ozone depletion and global warming, therefore, there is an opportunity for the introduction of products that are designed to eliminate VOC emissions from industrial processes. nGimat's goal is to release new ionic liquid solvents that meet these needs within 3-4 years. nGimat will license materials developed under Phase II to companies that manufacture pharmaceuticals, intermediates, performance chemicals, organic solvents or related products. Organic solvents play a major role in the synthesis of asymmetric drugs and intermediates, but many organic solvents are volatile and are harmful to the environment and to human health. Ionic liquid solvents offer a non-volatile alternative to replace volatile solvents in asymmetric drug synthesis. A new family of ionic liquid solvents will be investigated for their use in asymmetric synthesis.