Miniature Low-Noise High-Quality MRI Preamplifiers

微型低噪声高质量 MRI 前置放大器

• 批准号: 7326646
• 负责人: Hiroyuki Fujita
• 金额: $ 11.79万
• 依托单位: QUALITY ELECTRODYNAMICS, LLC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7326646
• 关键词: Address; Anatomy; Area; Blur; Calibration; Cancer Detection; Complex; Device Designs; Diagnostic; Dimensions; Disease; Documentation; Equipment Design; Evaluation; Facility Construction Funding Category; Frequencies; Future; Goals; Heart; Human; Human Resources; Image; Industry; Lung; Magnetic Resonance Imaging; Marketing; Mechanics; Medical; Medical Imaging; Methods; Mission; Modality; Motion; Noise; Numbers; Patients; Performance; Platelet Factor 4; Positioning Attribute; Printing; Procedures; Process; RF coil; Range; Safety; Scanning; Source; Speed; Staging; System; Technology; Testing; Time; Universities; Work; abstracting; clinical application; commercialization; computerized data processing; design; electric impedance; instrument; miniaturize; prototype; size

DESCRIPTION (provided by applicant): Miniature Low-Noise High-Quality MRI Preamplifiers Abstract As a start-up high-RF-technology company with an outstanding core of technical personnel, Future Instruments LLC has the mission to be the first industrial group to design, prototype, test, and manufacture new "miniature" preamplifiers in RoHS compliance for the medical systems industry in MRI. One of the fastest growing clinical applications in this powerful medical imaging modality is the so-called parallel imaging method where multiple receive coils are used in simultaneous signal processing to speed up imaging. The ability to reduce imaging time by a factor of 4 or more without a serious compromise of image quality is very important for patient comfort and picture fidelity. Examples are the reduction of blurring for human anatomies in motion, such as the heart and lung, and the time required for certain scanning procedures where the patients must hold their breath. To take full advantage of highly parallel imaging and the concomitant enhancement of disease diagnostics such as detection of cancer, large numbers of RF coils are required. While as many as 128 receiver-channel coils have been combined in some systems presently under study, most commercial RF coils have no more than 8 channels. Perhaps the biggest challenge in building these complex RF circuits is the size of the preamplifiers to be integrated in each coil. There is no existing commercial preamplifier small enough for the large numbers of channels envisioned. Preamplifiers in MRI are different from other technical areas in the need for low-input impedance (5 Ohms or less), nonmagnetic materials (to reduce image distortion), extremely low-noise figures, and robustness in the 64-300 MHz frequency range. In Future Instruments' mission to develop precisely what is needed for the many-channel RF system, their core competency and that of their collaborators at Case Western Reserve University is perfectly positioned 1) to design and optimize the circuit, printed circuit board, and selection of sourcing components and external prototyping firms, 2) to test a complete list of quality and safety factors including noise figure, stability, low-input impedance and linearity tests using network analyzers, spectrum analyzers and specialized test setups. The extensive criteria for this evaluation have been delineated in preliminary work, and the project target is to determine the performance level of a set of 200 preproduction preamplifiers and reach a decision of whether to go forward with the commercialization process or to revisit the device design stage to address any remaining performance problems. The long-term goal is to become a main supplier of new high-quality low-noise miniature preamplifiers for the MRI hardware industry.

描述（由申请人提供）：微型低噪声高质量MRI PREAKPRIFIERs摘要作为一家启动高级RF技术公司，具有出色的技术人员核心，Future Instruments LLC的使命是成为第一个设计，原型，测试和制造新的“ Miniature” PreakeArifiers在ROHS Compliance for Rohs Systems Systems Systems Systems Systems Systems Systems Commutiance in Medical Systems Commutiance in Medical Systems Commution in Mrim Inmi MRI MRI。在这种强大的医学成像方式中，增长最快的临床应用之一是所谓的并行成像方法，其中多个接收线圈同时使用信号处理来加快成像。在不严重折衷图像质量的情况下，将成像时间减少4或更多的能力对于患者的舒适性和图片保真度非常重要。例子是减少运动中的人类解剖学模糊，例如心脏和肺部，以及某些扫描程序必须屏住呼吸所需的时间。要充分利用高度平行的成像，并伴随着疾病诊断（例如癌症检测）的增强，需要大量RF线圈。尽管目前正在研究的某些系统中已经合并了多达128个接收器通道线圈，但大多数商业RF线圈的渠道不超过8个通道。构建这些复杂的RF电路的最大挑战也许是每个线圈中要集成的前置放大器的大小。没有现有的商业前置放大器，足以容纳大量渠道。 MRI中的前置放大剂与其他技术领域不同，需要低输入阻抗（5欧姆或更少），非磁性材料（减少图像失真），极低的噪声数字和64-300 MHz频率范围内的稳健性。 In Future Instruments' mission to develop precisely what is needed for the many-channel RF system, their core competency and that of their collaborators at Case Western Reserve University is perfectly positioned 1) to design and optimize the circuit, printed circuit board, and selection of sourcing components and external prototyping firms, 2) to test a complete list of quality and safety factors including noise figure, stability, low-input impedance and linearity tests using network analyzers, spectrum分析仪和专业测试设置。该评估的广泛标准已在初步工作中划定，项目目标是确定200套200前制作前置放大器的绩效水平，并决定是否要继续进行商业化过程或重新审视设备设计阶段以解决任何剩余的绩效问题。长期目标是成为MRI硬件行业的新高质量低噪声微型前置放大器的主要供应商。