A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery

牙周微创手术统一手术器械系统

• 批准号: 7269227
• 负责人: Stephen K. Harrel
• 金额: $ 10万
• 依托单位: DENTAL DESIGNS OF DALLAS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7269227
• 关键词: Adoption; Adult; Allografting; American; Autologous Transplantation; Biomedical Engineering; Bone Growth; Bone Transplantation; Cardiovascular Diseases; Cataract; Chronic; Clinical; Debridement; Dental; Dentistry; Development; Devices; Endoscopes; Esthetics; Evaluation; Goals; Growth; Human; Imagery; Inflammatory; Invasive; Journals; Laboratories; Legal patent; Medical; Medicine; Methods; Modification; Morbidity - disease rate; Natural regeneration; Operative Surgical Procedures; Optics; Organ Transplantation; Paper; Patients; Performance; Periodontal Diseases; Periodontic specialty; Personal Communication; Personal Satisfaction; Phase; Phase I Clinical Trials; Placement; Postoperative Pain; Procedures; Publishing; Purpose; Recombinants; Reporting; Research; Score; Site; Speed; Surgeon; Surgical Instruments; Surgical incisions; System; Techniques; Technology; Time; Tissues; Tooth Loss; Tooth structure; Trauma; Ultrasonics; Water; Work; base; bone; bone loss; bone morphogenic protein; concept; design; desire; enamel matrix proteins; evaluation/testing; improved; instrument; instrumentation; pressure; productivity loss; prototype; research clinical testing; soft tissue; success; treatment site; wound

DESCRIPTION (provided by applicant): This effort is aimed at developing an effective, easily utilized, and unified system for performing periodontal minimally invasive surgery. Periodontal minimally invasive surgery (MIS) is a method for regenerating lost bone and tooth support resulting from periodontal disease.2-6 MIS utilizes much smaller incisions than traditional periodontal surgery, has a record of clinical regeneration of lost tissue, results in less patient trauma, less postoperative pain, better post surgical esthetics, and a more rapid return to normal function. Periodontal minimally invasive surgery is currently in use but no surgical instrument system exists that allows a surgeon to easily incorporate MIS into their surgical routine. The development of a unified MIS instrument system will consist of: (1) The fabrication of an endoscope visualization system that overcomes the clinical difficulties encountered with current visualization systems and (2) the fabrication of instruments for improved soft tissue debridement through the small surgical opening used with MIS. The long term goal is to produce a commercially available unified surgical instrument system for performing MIS. This system will allow the surgeon to easily perform MIS and will bring to the patient the advantages of MIS. The commercial potential for such a system is very high because of patient desire for the smallest and least invasive surgery possible. The commercial potential will expand as new bioengineered materials, currently under development, become available. The Phase 1 effort will build on existing bench top prototypes developed by Dental Designs of Dallas. Flexible medical endoscopes will be modified for use in MIS. Methods for soft tissue debridement will be developed by completely redesigning the currently available instrumentation (D'granulator, patent held by Dental Designs of Dallas) and the adaptation of medical ultrasonic "chopper" technology (Phacoemulsifier for cataracts). The developed prototypes will be evaluated in the laboratory by a group of periodontal surgical consultants who currently use MIS or who are leading, published, periodontal surgeons. The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS.

描述（由申请人提供）：这项工作旨在开发一种有效、易于使用和统一的系统，用于进行牙周微创手术。牙周病微创手术（MIS）是一种再生牙周病导致的骨和牙齿支持缺失的方法。2 -6 MIS使用比传统牙周手术小得多的切口，具有临床组织缺失再生的记录，导致患者创伤更少，术后疼痛更少，术后美学更好，更快恢复正常功能。目前正在使用牙周微创手术，但不存在允许外科医生将MIS轻松纳入其手术程序的手术器械系统。统一MIS工具系统的开发将包括：（1）制造内窥镜可视化系统，克服当前可视化系统遇到的临床困难;（2）制造工具，通过MIS使用的小手术开口改善软组织清创。长期目标是生产用于执行MIS的市售统一手术器械系统。该系统将允许外科医生轻松执行MIS，并将为患者带来MIS的优势。这种系统的商业潜力非常高，因为患者希望尽可能进行最小和侵入性最小的手术。随着目前正在开发的新的生物工程材料的可用，商业潜力将扩大。第一阶段的工作将建立在现有的台式原型开发的牙科设计达拉斯。将对医用软式内窥镜进行改良，以用于MIS。将通过完全重新设计目前可用的仪器（D 'Escene，达拉斯的Dental Designs拥有的专利）和采用医学超声“斩波器”技术（白内障超声乳化器）来开发软组织清创方法。开发的原型将在实验室中由一组目前使用MIS或领先的牙周外科医生的牙周外科顾问进行评估。基于手术顾问评价和评分的最终系统将用于MIS的II期多中心对照临床评价。

项目成果

Videoscope-assisted minimally invasive periodontal surgery (V-MIS).

视频内窥镜辅助微创牙周手术（V-MIS）。

• DOI: 10.1111/jcpe.12294
• 发表时间: 2014
• 期刊: Journal of clinical periodontology
• 影响因子: 6.7
• 作者: Harrel,StephenK;Abraham,CelesteM;Rivera-Hidalgo,Francisco;Shulman,JayD;Nunn,MarthaE
• 通讯作者: Nunn,MarthaE

Tissue resistance to soft tissue emphysema during minimally invasive periodontal surgery.

微创牙周手术期间组织对软组织气肿的抵抗力。

• DOI: 10.5005/jp-journals-10024-1247
• 发表时间: 2012
• 期刊: The journal of contemporary dental practice
• 作者: Harrel,StephenK;Abraham,CelesteM;Rivera-Hidalgo,Francisco
• 通讯作者: Rivera-Hidalgo,Francisco