Multiplexed Personal Monitoring of Airborne Toxins

空气中毒素的多重个人监测

• 批准号: 7285312
• 负责人: Bharat R Acharya
• 金额: $ 22.16万
• 依托单位: PLATYPUS TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7285312
• 关键词: Address; Affect; Binding; Carbamates; Chemicals; Chemistry; Chronic; Class; Complex; Data; Detection; Devices; Discrimination; Dose; Environment; Environmental Monitoring; Environmental Pollution; Exposure to; Health; Individual; Investigation; Measurement; Measures; Metals; Methodology; Monitor; Organophosphates; Ornithorhynchus anatinus; Pesticides; Phase; Public Health; Salts; Sensitivity and Specificity; Structure; Surface; Technology; Toxic Environmental Substances; Toxin; Week; base; day; design; innovation; liquid crystal; nanoscale; nanostructured; planetary Atmosphere; research study; vapor

DESCRIPTION (provided by applicant): Quantitative monitoring of personal exposure to environmental toxins is currently limited by expense, inconvenience and lack of appropriate technology, yet such monitoring is needed for investigation of health effects caused by low dose, chronic exposure to compounds such as pesticides or industrial toxins. We have previously demonstrated that low concentrations of a semi-volatile organophosphate pesticide can be detected from a vapor phase by utilizing chemically functionalized, nanostructured surfaces and liquid crystals (Platypus( technology). What is needed, however, is a monitor that simultaneously measures exposure to multiple compounds. In this proposal, we will demonstrate the feasibility of developing Platypus( technology for the quantitative and simultaneous detection of two different classes of semi-volatile pesticides (carbamates and organophosphates) and for the discrimination of specific compounds within each class of pesticide. The technology developed in this project can be adapted for detection of other industrial or environmental contaminants that are semi-volatile, and thus it has the potential to serve as the basis for a broadly useful, convenient and inexpensive class of passive monitors for multi-compound personal exposure assessment and environmental monitoring. In this proposal, we are developing a small, inexpensive wearable device which will provide a measurement of an individual's exposure to multiple chemicals present in his or her environment over a period of a day to a few weeks. This data is essential for associating exposure to specific compounds with adverse affects on public health.

描述（由申请人提供）：目前，由于费用、不便和缺乏适当的技术，对个人接触环境毒素的定量监测受到限制，但需要进行这种监测，以调查低剂量、长期接触农药或工业毒素等化合物所造成的健康影响。我们先前已经证明，通过利用化学功能化的纳米结构表面和液晶，可以从气相中检测到低浓度的半挥发性有机磷酸酯农药（Platypus（technology）.然而，需要的是一种同时测量对多种化合物的暴露的监测器。在本提案中，我们将论证开发Platypus（用于定量和同时检测两种不同类别的半挥发性农药（氨基甲酸酯和有机磷酸酯）以及区分每类农药中特定化合物的技术）的可行性。本项目开发的技术可适用于检测其他半挥发性工业或环境污染物，因此，它有可能成为广泛有用、方便和廉价的多化合物个人接触评估和环境监测无源监测器的基础。在这项提案中，我们正在开发一种小型、廉价的可穿戴设备，它将提供一个人在一天到几周的时间内暴露于他或她环境中的多种化学物质的测量。这些数据对于将接触特定化合物与对公共健康的不利影响联系起来至关重要。