Liquid crystal-based sensor for real-time detection of O3, CO and CO2

描述（由申请人提供） 该项目的目标是开发一种支持GPS的多分析物传感器，可以检测和测量空气中存在的痕量气体，特别是臭氧，一氧化碳和二氧化碳气体的暴露。这种传感器是基于创新的开发锚定的液晶与金属离子功能化的表面。在初步研究中，我们已经证明了识别选择性结合臭氧的金属组合的能力，并设计了多阵列的金属，以创建特定于官能团的指纹。我们还展示了使用这种新技术快速（约10秒）测量暴露于ppb浓度的有机磷酸盐化合物。我们创建的传感表面可以被调整为可逆的，不受湿度的影响，并以剂量依赖的方式响应。这些数据有力地支持了PlatypusTM技术作为一种紧凑的、多分析物的、可现场部署的个人设备用于检测痕量气体暴露的可行性。在本提案中，我们将开发一个传感器子系统，并将其与支持GPS的组件集成，这些组件可跟踪和存储信息，例如暴露程度、暴露时间和持续时间以及暴露事件的确切位置。我们的预期产品将允许简单的数据上传到计算机，并将在现场条件下进行测试。需要这种产品来帮助了解人类对环境暴露的敏感性。

DESCRIPTION (provided by applicant) The goal of this project is to develop a GPS-enabled multi-analyte sensor that can detect and measure exposure to trace gases present in air, specifically ozone, carbon monoxide and carbon dioxide gases. This sensor is based on the innovative exploitation of the anchoring of liquid crystals to a surface functionalized with metal ions. In preliminary studies we have demonstrated the ability to identify combinations of metals that selectively bind ozone and to design multi-arrays of metals that create fingerprints specific for functional groups. We also demonstrated the use of this new technology to rapidly (~ 10 seconds) measure exposure to ppb concentrations of an organophosphate compound. The sensing surfaces we created could be tuned to be reversible, were unaffected by humidity, and responded in a dose-dependent manner. These data strongly support the feasibility of PlatypusTM technology as the basis of a compact, multi-analyte, field deployable personal device for detection of exposure to trace gases. In this proposal we will develop a sensor subsystem and integrate it with GPS-enabled components that track and store information such as degree of exposure, time and duration of exposure and exact location of exposure events. Our intended product will allow simple uploading of the data to a computer and will be tested under field conditions. Such a product is needed to facilitate the understanding of human susceptibility to environmental exposures.