Innovative Implantable Telemetric Ethanol Biosensor

创新的植入式遥测乙醇生物传感器

• 批准号: 7257854
• 负责人: RH Farahi
• 金额: $ 15万
• 依托单位: TELESENSORS, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-10 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257854
• 关键词: Acetaldehyde; Alcohol consumption; Alcohols; Area; Arts; Behavior; Biocompatible; Biological; Biosensor; Body Temperature; Calibration; Cells; Characteristics; Chemicals; Collaborations; Communication; Computer software; Condition; Data; Data Collection; Data Reporting; Data Storage and Retrieval; Detection; Development; Devices; Dimensions; Drug Kinetics; Drug usage; Electronics; Ensure; Environment; Ethanol; Funding; Future; Generations; Goals; Heart Rate; Housing; Human; Human Resources; Humidity; Implant; Indiana; Individual; Institutes; Laboratories; Legal; Liquid substance; Measurement; Medical Research; Microprocessor; Modeling; Monitor; Motion; Noise; Numbers; Operative Surgical Procedures; Pattern; Performance; Pharmaceutical Preparations; Phase; Physiological; Polymers; Range; Rate; Rattus; Reaction Time; Research; Research Personnel; Research Project Grants; Research Subjects; Resolution; Semiconductors; Signal Transduction; Simulate; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Smoking; Subcutaneous Tissue; System; Techniques; Telemetry; Temperature; Temperature Sense; Tennessee; Testing; Time; Universities; Work; alcohol exposure; alcohol measurement; alcohol monitoring; alcoholism/alcohol abuse; analog; aqueous; base; biomaterial compatibility; clinical application; computerized data processing; design; desire; experience; foot; implantation; implanted sensor; innovation; innovative technologies; miniaturize; monitoring device; remote sensor; sensor; size; time interval; transmission process

DESCRIPTION (provided by applicant): Innovative technologies for sensitive and selective monitoring of alcohol and its metabolites in humans are of continuing importance to the National Institute of Alcoholism and Alcohol Abuse (NIAAA). Although there has been progress in developing real-time, remote sensors and systems in recent years, the performance of these systems is generally insufficient for demanding applications requiring miniaturized continuous monitoring of body functions (e.g. temperature, heart rate, etc.) along with alcohol and other possible chemical constituents while being unconstrained by conventional monitoring devices. Telesensors Inc. proposes to design, develop, fabricate, test and commercialize a miniaturized, implantable telemetric system for transducing alcohol concentrations and body temperatures in subcutaneous tissue. This system will include onboard data collection and analysis and periodic telemetric reporting of the data to a remote base station for storage and further analysis. The combination of multi-channel sensing and data collection capacity, implantability, micro-miniature size, and physiological calibration, all supported by signal processing software that tailors the measurements made to an individual's pharmacokinetics, best represents the state-of-the-art in bio-medical research sought by NIAAA. The proposed system will promote both research and clinical applications. In particular, the variety of biological signals that future researchers could choose as targets for exploiting unused data collection channels built into the. proposed system promises the opportunity to track the progression of nearly any phase of alcohol related illness. As far as is known, the approach we propose offers the only system for direct, continuous, measurement of alcohol concentrations.

描述（由申请人提供）： 用于敏感和选择性地监测人体内酒精及其代谢物的创新技术对国家酒精中毒和酒精滥用研究所（NIAAA）具有持续的重要性。虽然近年来在开发实时、远程传感器和系统方面取得了进展，但这些系统的性能通常不足以满足要求小型化连续监测身体功能（例如，温度、心率等）的苛刻应用。沿着酒精和其它可能的化学成分，同时不受常规监测装置的约束。Telesensors Inc.建议设计、开发、制造、测试和商业化一种微型化的、可植入的遥测系统，用于在皮下组织中转换酒精浓度和体温。该系统将包括机载数据收集和分析，并定期向远程基站遥测报告数据，以供储存和进一步分析。多通道传感和数据收集能力，可植入性，微型尺寸和生理校准的组合，所有这些都由信号处理软件支持，该软件可根据个体的药代动力学进行量身定制测量，最能代表NIAAA寻求的最先进的生物医学研究。该系统将促进研究和临床应用。特别是，未来的研究人员 可以选择作为利用内置的未使用的数据收集通道的目标。拟议系统 它承诺有机会跟踪几乎任何阶段的酒精相关疾病的进展。据了解，我们提出的方法提供了唯一的系统，直接，连续，测量酒精浓度。