Dietary intake of antioxidants, hippocampal volume, and risk of cognitive decline

抗氧化剂的膳食摄入量、海马体积和认知能力下降的风险

• 批准号: 7407025
• 负责人: ELIZABETH E DEVORE
• 金额: $ 4.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407025
• 关键词: Age; Alzheimer' s Disease; Antioxidants; Ascorbic Acid; Berry; Carotene; Carotenoids; Clinical; Clinical Trials; Cognitive; Dementia; Diet; Dietary intake; Disease; Elderly; Epidemiologic Studies; Event; Flavonoids; Food; Frequencies; Grant; Health; Hippocampus (Brain); Impaired cognition; Intake; Intervention; Life; Life Style; Linear Regressions; Magnetic Resonance Imaging; Measures; Modeling; Modification; Nerve Degeneration; Nurses' Health Study; Nutrient; Outcome; Oxidative Stress; Pathogenesis; Population; Prevention strategy; Preventive; Purpose; Questionnaires; Reporting; Research; Risk; Risk Factors; Scanning; Score; Staging; Symptoms; Telephone; Thinking; Tocopherols; Vitamin E; aging brain; base; cognitive function; cohort; dietary antioxidant; disorder risk; hippocampal atrophy; lycopene; pre-clinical; prospective; research study

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) likely begins several decades before the onset of clinical symptoms, and preclinical changes such as hippocampal atrophy and early cognitive decline are strong predictors of dementia risk later in life. In addition, oxidative stress is thought to be an important, early pathogenic event in AD, thus antioxidants could be highly relevant to the study of hippocampal volume and early cognitive decrements. Experimental studies show that antioxidants can protect against neuronal degeneration, although epidemiologic studies of antioxidant supplements have found no substantial cognitive benefit. Nonetheless, preliminary dietary studies are intriguing, suggesting that the wider variety of antioxidants available in foods may be most important for reducing brain aging. Thus, the proposed research will explore the effects of dietary intake of antioxidant nutrients, antioxidant-rich foods, and total antioxidant capacity (assessed by a diet-based "antioxidant score") on hippocampal atrophy and early cognitive decline. These analyses will be conducted in two, large, prospective cohorts of older adults; specifically, analyses of hippocampal atrophy (using magnetic resonance imaging to estimate hippocampal volume) will be carried out in the Rotterdam Scan Study, and those of early cognitive decline (based on a validated telephone battery of cognitive assessments) in the Nurses' Health Study. Dietary information in both cohorts is collected using semi-quantitative food frequency questionnaires validated in their respective populations. To quantify antioxidant relationships with these outcomes, multivariate linear regression and random effects models will be used and consideration given to covariate adjustments for a variety of health and lifestyle factors. Together, these results could eventually help to inform preventive strategies for dementia, as intervention probably will be most effective at the earliest likely stages of disease.

描述(申请人提供)：阿尔茨海默病(AD)很可能在临床症状出现前几十年就开始了，临床前的变化，如海马体萎缩和早期认知能力下降，是晚年痴呆症风险的强烈预测因素。此外，氧化应激被认为是AD的一个重要的早期致病事件，因此抗氧化剂可能与海马体体积和早期认知功能减退的研究高度相关。实验研究表明，抗氧化剂可以防止神经元退化，尽管对抗氧化剂补充剂的流行病学研究没有发现实质性的认知益处。尽管如此，初步的饮食研究还是耐人寻味的，表明食物中可获得的更多种类的抗氧化剂可能对减缓大脑衰老最重要。因此，拟议的研究将探讨 饮食摄入抗氧化剂营养素、富含抗氧化剂的食物以及总的抗氧化能力(通过基于饮食的“抗氧化剂评分”进行评估)对海马区萎缩和早期认知功能衰退的影响。这些分析将在两个大型的老年人预期队列中进行；具体地说，对海马区萎缩的分析(使用磁共振成像来估计海马体体积)将在鹿特丹扫描研究中进行，早期认知衰退的分析将在护士健康研究中进行(基于经过验证的认知评估电话电池)。两个队列中的饮食信息都是使用在各自人口中验证的半定量食物频率问卷收集的。为了量化抗氧化剂与这些结果的关系，将使用多变量线性回归和随机影响模型，并考虑对各种健康和生活方式因素的协变量调整。总而言之，这些结果最终可能有助于为痴呆症的预防战略提供参考，因为干预可能在疾病的最早阶段最有效。