Dietary intake of antioxidants, hippocampal volume, and risk of cognitive decline

抗氧化剂的膳食摄入量、海马体积和认知能力下降的风险

• 批准号: 7753839
• 负责人: ELIZABETH E DEVORE
• 金额: $ 5.05万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7753839
• 关键词: Age; Alzheimer' s Disease; Antioxidants; Ascorbic Acid; Berry; Carotene; Carotenoids; Clinical; Clinical Trials; Cognitive; Dementia; Diet; Dietary intake; Disease; Elderly; Epidemiologic Studies; Event; Flavonoids; Food; Frequencies; Grant; Health; Hippocampus (Brain); Impaired cognition; Intake; Intervention; Life; Linear Regressions; Magnetic Resonance Imaging; Measures; Modeling; Modification; Nerve Degeneration; Nurses' Health Study; Nutrient; Outcome; Oxidative Stress; Pathogenesis; Population; Prevention strategy; Preventive; Questionnaires; Reporting; Research; Risk; Risk Factors; Scanning; Staging; Symptoms; Telephone; Tocopherols; Vitamin E; aging brain; base; cognitive function; cohort; dietary antioxidant; disorder risk; hippocampal atrophy; lifestyle factors; lycopene; pre-clinical; prospective; research study

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) likely begins several decades before the onset of clinical symptoms, and preclinical changes such as hippocampal atrophy and early cognitive decline are strong predictors of dementia risk later in life. In addition, oxidative stress is thought to be an important, early pathogenic event in AD, thus antioxidants could be highly relevant to the study of hippocampal volume and early cognitive decrements. Experimental studies show that antioxidants can protect against neuronal degeneration, although epidemiologic studies of antioxidant supplements have found no substantial cognitive benefit. Nonetheless, preliminary dietary studies are intriguing, suggesting that the wider variety of antioxidants available in foods may be most important for reducing brain aging. Thus, the proposed research will explore the effects of dietary intake of antioxidant nutrients, antioxidant-rich foods, and total antioxidant capacity (assessed by a diet-based "antioxidant score") on hippocampal atrophy and early cognitive decline. These analyses will be conducted in two, large, prospective cohorts of older adults; specifically, analyses of hippocampal atrophy (using magnetic resonance imaging to estimate hippocampal volume) will be carried out in the Rotterdam Scan Study, and those of early cognitive decline (based on a validated telephone battery of cognitive assessments) in the Nurses' Health Study. Dietary information in both cohorts is collected using semi-quantitative food frequency questionnaires validated in their respective populations. To quantify antioxidant relationships with these outcomes, multivariate linear regression and random effects models will be used and consideration given to covariate adjustments for a variety of health and lifestyle factors. Together, these results could eventually help to inform preventive strategies for dementia, as intervention probably will be most effective at the earliest likely stages of disease.

描述（由申请人提供）：阿尔茨海默病（AD）可能在临床症状出现前几十年就开始了，临床前的变化，如海马萎缩和早期认知能力下降，是晚年痴呆症风险的有力预测因素。此外，氧化应激被认为是阿尔茨海默病的一个重要的早期致病事件，因此抗氧化剂可能与海马体体积和早期认知能力下降的研究高度相关。实验研究表明，抗氧化剂可以防止神经元退化，尽管抗氧化剂补充剂的流行病学研究没有发现实质性的认知益处。尽管如此，初步的饮食研究还是很有趣的，表明食物中更多种类的抗氧化剂对减少大脑衰老可能是最重要的。因此，本研究将探讨

项目成果

Dietary intakes of berries and flavonoids in relation to cognitive decline.

• DOI: 10.1002/ana.23594
• 发表时间: 2012-07
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Devore, Elizabeth E.;Kang, Jae Hee;Breteler, Monique M. B.;Grodstein, Francine
• 通讯作者: Grodstein, Francine